Metal Response in Cupriavidus metallidurans, Volume II: Insights into the Structure-Function Relationship of Proteins

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Abstract

Bacteria such as Cupriavidus metallidurans have developed different strategies for tolerating toxic levels of metal ions. Metal ion resistance requires the contribution of multiple layers of mechanisms, the most efficient being the efflux of the noxious cations out of the cell regulated by transport systems. Structural and functional data from bacterial primary and secondary transporters are outlined and detailed for the corresponding C. metallidurans proteins. Next, the available high-resolution threedimensional structures of C. metallidurans proteins involved in metal resistance mechanisms are reviewed and their structure-function relationship is discussed.

Details

Original languageEnglish
Place of PublicationSwitzerland
PublisherSpringer
Number of pages70
Edition1
ISBN (Print)978-3-319-20623-3
StatePublished - Jul 2015

Publication series

NameSpringerBriefs in Biometals

Keywords

  • Anti-sigma factor, Cation diffusion facilitator, Chemiosmotic efflux system, Major facilitator superfamily, Membrane fusion protein, Metal ion efflux, P-type ATPase, Resistance nodulation cell division

ID: 314284