Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station

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Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station. / Guéguinou, Nathan; Jeandel, Jérémy; Kaminski, Sandra; Baatout, Sarah; Ghislin, Stéphanie; Frippiat, Jean-Pol.

In: International Journal of Molecular Sciences, Vol. 20, 1579, 02.04.2019, p. 1-16.

Research output: Contribution to journalArticlepeer-review

Harvard

Guéguinou, N, Jeandel, J, Kaminski, S, Baatout, S, Ghislin, S & Frippiat, J-P 2019, 'Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station', International Journal of Molecular Sciences, vol. 20, 1579, pp. 1-16. https://doi.org/10.3390/ijms20071579

APA

Guéguinou, N., Jeandel, J., Kaminski, S., Baatout, S., Ghislin, S., & Frippiat, J-P. (2019). Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station. International Journal of Molecular Sciences, 20, 1-16. [1579]. https://doi.org/10.3390/ijms20071579

Vancouver

Guéguinou N, Jeandel J, Kaminski S, Baatout S, Ghislin S, Frippiat J-P. Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station. International Journal of Molecular Sciences. 2019 Apr 2;20:1-16. 1579. https://doi.org/10.3390/ijms20071579

Author

Guéguinou, Nathan ; Jeandel, Jérémy ; Kaminski, Sandra ; Baatout, Sarah ; Ghislin, Stéphanie ; Frippiat, Jean-Pol. / Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station. In: International Journal of Molecular Sciences. 2019 ; Vol. 20. pp. 1-16.

Bibtex - Download

@article{a4f986b348aa42649522eca908929e44,
title = "Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station",
abstract = "The complement system plays an important role in inflammation, innate and acquired immunity, as well as homeostasis. Despite these functions, the effects of spaceflight conditions on the complement system have not yet been intensively studied. Consequently, we investigated the effects of five types of chronic stressors, similar to those encountered during a stay onboard the International Space Station, on C3 expression in larvae of the urodele amphibian Pleurodeles waltl. We focused on C3 because it is a critical component of this system. These studies were completed by the analysis of adult mice exposed to two models of inflight stressors. Our data show that simulating space radiation, or combining a modification of the circadian rhythm with simulated microgravity, affects the amount of C3 proteins. These results suggest that C3 expression could be modified under real spaceflight conditions, potentially increasing the risk of inflammation and associated tissue damage.",
keywords = "spaceflight, gravity, amphibian, immunity, inflammation",
author = "Nathan Gu{\'e}guinou and J{\'e}r{\'e}my Jeandel and Sandra Kaminski and Sarah Baatout and St{\'e}phanie Ghislin and Jean-Pol Frippiat",
note = "Score=10",
year = "2019",
month = apr,
day = "2",
doi = "10.3390/ijms20071579",
language = "English",
volume = "20",
pages = "1--16",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "MDPI",

}

RIS - Download

TY - JOUR

T1 - Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station

AU - Guéguinou, Nathan

AU - Jeandel, Jérémy

AU - Kaminski, Sandra

AU - Baatout, Sarah

AU - Ghislin, Stéphanie

AU - Frippiat, Jean-Pol

N1 - Score=10

PY - 2019/4/2

Y1 - 2019/4/2

N2 - The complement system plays an important role in inflammation, innate and acquired immunity, as well as homeostasis. Despite these functions, the effects of spaceflight conditions on the complement system have not yet been intensively studied. Consequently, we investigated the effects of five types of chronic stressors, similar to those encountered during a stay onboard the International Space Station, on C3 expression in larvae of the urodele amphibian Pleurodeles waltl. We focused on C3 because it is a critical component of this system. These studies were completed by the analysis of adult mice exposed to two models of inflight stressors. Our data show that simulating space radiation, or combining a modification of the circadian rhythm with simulated microgravity, affects the amount of C3 proteins. These results suggest that C3 expression could be modified under real spaceflight conditions, potentially increasing the risk of inflammation and associated tissue damage.

AB - The complement system plays an important role in inflammation, innate and acquired immunity, as well as homeostasis. Despite these functions, the effects of spaceflight conditions on the complement system have not yet been intensively studied. Consequently, we investigated the effects of five types of chronic stressors, similar to those encountered during a stay onboard the International Space Station, on C3 expression in larvae of the urodele amphibian Pleurodeles waltl. We focused on C3 because it is a critical component of this system. These studies were completed by the analysis of adult mice exposed to two models of inflight stressors. Our data show that simulating space radiation, or combining a modification of the circadian rhythm with simulated microgravity, affects the amount of C3 proteins. These results suggest that C3 expression could be modified under real spaceflight conditions, potentially increasing the risk of inflammation and associated tissue damage.

KW - spaceflight

KW - gravity

KW - amphibian

KW - immunity

KW - inflammation

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/33502495

U2 - 10.3390/ijms20071579

DO - 10.3390/ijms20071579

M3 - Article

VL - 20

SP - 1

EP - 16

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

M1 - 1579

ER -

ID: 5034855