Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia

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Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia. / Strewe, Claudia; Thieme, Detlef; Dangoisse, Carole; Fiedel, Barbara; van den Berg, Floris; Bauer, Holger; Salam, Alex P.; Gössmann-Lang, Petra; Campolongo, Patrizia; Moser, Dominique; Quintens, Roel; Moreels, Marjan; Baatout, Sarah; Kohlberg, Eberhard ; Schelling, Gustav; Choukèr, Alexander; Feuerecker, Matthias.

In: Frontiers in Physiology, Vol. 9, 1647, 26.11.2018.

Research output: Contribution to journalArticle

Harvard

Strewe, C, Thieme, D, Dangoisse, C, Fiedel, B, van den Berg, F, Bauer, H, Salam, AP, Gössmann-Lang, P, Campolongo, P, Moser, D, Quintens, R, Moreels, M, Baatout, S, Kohlberg, E, Schelling, G, Choukèr, A & Feuerecker, M 2018, 'Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia' Frontiers in Physiology, vol 9, 1647. DOI: 10.3389/fphys.2018.01647

APA

Strewe, C., Thieme, D., Dangoisse, C., Fiedel, B., van den Berg, F., Bauer, H., ... Feuerecker, M. (2018). Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia. Frontiers in Physiology, 9, [1647]. DOI: 10.3389/fphys.2018.01647

Vancouver

Strewe C, Thieme D, Dangoisse C, Fiedel B, van den Berg F, Bauer H et al. Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia. Frontiers in Physiology. 2018 Nov 26;9. 1647. Available from, DOI: 10.3389/fphys.2018.01647

Author

Strewe, Claudia; Thieme, Detlef; Dangoisse, Carole; Fiedel, Barbara; van den Berg, Floris; Bauer, Holger; Salam, Alex P.; Gössmann-Lang, Petra; Campolongo, Patrizia; Moser, Dominique; Quintens, Roel; Moreels, Marjan; Baatout, Sarah; Kohlberg, Eberhard ; Schelling, Gustav; Choukèr, Alexander; Feuerecker, Matthias / Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia.

In: Frontiers in Physiology, Vol. 9, 1647, 26.11.2018.

Research output: Contribution to journalArticle

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@article{45d31801eac84a69a9d34c98e18548ce,
title = "Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia",
keywords = "endocannabinoids, catecholamines, glucocorticoids, hypobaric hypoxia, high altitude, Antarctica",
author = "Claudia Strewe and Detlef Thieme and Carole Dangoisse and Barbara Fiedel and {van den Berg}, Floris and Holger Bauer and Salam, {Alex P.} and Petra Gössmann-Lang and Patrizia Campolongo and Dominique Moser and Roel Quintens and Marjan Moreels and Sarah Baatout and Eberhard Kohlberg and Gustav Schelling and Alexander Choukèr and Matthias Feuerecker",
note = "Score=10",
year = "2018",
month = "11",
doi = "10.3389/fphys.2018.01647",
volume = "9",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Media",

}

RIS - Download

TY - JOUR

T1 - Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia

AU - Strewe,Claudia

AU - Thieme,Detlef

AU - Dangoisse,Carole

AU - Fiedel,Barbara

AU - van den Berg,Floris

AU - Bauer,Holger

AU - Salam,Alex P.

AU - Gössmann-Lang,Petra

AU - Campolongo,Patrizia

AU - Moser,Dominique

AU - Quintens,Roel

AU - Moreels,Marjan

AU - Baatout,Sarah

AU - Kohlberg,Eberhard

AU - Schelling,Gustav

AU - Choukèr,Alexander

AU - Feuerecker,Matthias

N1 - Score=10

PY - 2018/11/26

Y1 - 2018/11/26

N2 - The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. The seasonal shifts of complete daylight (summer) to complete darkness (winter) as well as massive changes in outside temperatures (down to 蚠80C at Concordia) during winter result in complete confinement of the crews from the outside world. In addition, the crew at Concordia is subjected to hypobaric hypoxia of 650 hPa as the station is situated at high altitude (3,233 m). We studied three expedition crews at Neumayer III (sea level) (n = 16) and two at Concordia (high altitude) (n = 15) to determine the effects of hypobaric hypoxia on hormonal/metabolic stress parameters [endocannabinoids (ECs), catecholamines, and glucocorticoids] and evaluated the psychological stress over a period of 11 months including winter confinement. In the Neumayer III (sea level) crew, EC and n-acylethanolamide (NAE) concentrations increased significantly already at the beginning of the deployment (p <0.001) whereas catecholamines and cortisol remained unaffected. Over the year, ECs and NAEs stayed elevated and fluctuated before slowly decreasing till the end of the deployment. The classical stress hormones showed small increases in the last third of deployment. By contrast, at Concordia (high altitude), norepinephrine concentrations increased significantly at the beginning (p <0.001) which was paralleled by low EC levels. Prior to the second half of deployment, norepinephrine declined constantly to end on a low plateau level, whereas then the EC concentrations increased significantly in this second period during the overwintering (p <0.001). Psychometric data showed no significant changes in the crews at either station. These findings demonstrate that exposition of healthy humans to the physically challenging extreme environment of Antarctica (i) has a distinct modulating effect on stress responses. Additionally, (ii) acute high altitude/hypobaric hypoxia at the beginning seem to trigger catecholamine release that downregulates the EC response. These results (iii) are not associated with psychological stress.

AB - The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. The seasonal shifts of complete daylight (summer) to complete darkness (winter) as well as massive changes in outside temperatures (down to 蚠80C at Concordia) during winter result in complete confinement of the crews from the outside world. In addition, the crew at Concordia is subjected to hypobaric hypoxia of 650 hPa as the station is situated at high altitude (3,233 m). We studied three expedition crews at Neumayer III (sea level) (n = 16) and two at Concordia (high altitude) (n = 15) to determine the effects of hypobaric hypoxia on hormonal/metabolic stress parameters [endocannabinoids (ECs), catecholamines, and glucocorticoids] and evaluated the psychological stress over a period of 11 months including winter confinement. In the Neumayer III (sea level) crew, EC and n-acylethanolamide (NAE) concentrations increased significantly already at the beginning of the deployment (p <0.001) whereas catecholamines and cortisol remained unaffected. Over the year, ECs and NAEs stayed elevated and fluctuated before slowly decreasing till the end of the deployment. The classical stress hormones showed small increases in the last third of deployment. By contrast, at Concordia (high altitude), norepinephrine concentrations increased significantly at the beginning (p <0.001) which was paralleled by low EC levels. Prior to the second half of deployment, norepinephrine declined constantly to end on a low plateau level, whereas then the EC concentrations increased significantly in this second period during the overwintering (p <0.001). Psychometric data showed no significant changes in the crews at either station. These findings demonstrate that exposition of healthy humans to the physically challenging extreme environment of Antarctica (i) has a distinct modulating effect on stress responses. Additionally, (ii) acute high altitude/hypobaric hypoxia at the beginning seem to trigger catecholamine release that downregulates the EC response. These results (iii) are not associated with psychological stress.

KW - endocannabinoids

KW - catecholamines

KW - glucocorticoids

KW - hypobaric hypoxia

KW - high altitude

KW - Antarctica

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/31717105

U2 - 10.3389/fphys.2018.01647

DO - 10.3389/fphys.2018.01647

M3 - Article

VL - 9

JO - Frontiers in Physiology

T2 - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 1647

ER -

ID: 4753235