Molecular characterization of endothelial cell response in the context of radiation-induced atherosclerosis

Research output: ThesisDoctoral thesis

Institutes & Expert groups

Documents & links

Abstract

Ionizing radiation is used for radiotherapeutic and diagnostic purposes, which can expose the heart and blood vessels, potentially causing cardiovascular diseases (CVDs). However, dose-dependency and associated molecular mechanisms are still elusive. Our work focused on endothelial cells based on previous information suggesting that ionizing radiation could promote atherosclerosis. We report that a single X-ray dose induces a time- and dose-dependent pro-atherosclerotic phenotype, linked with changes in cell cycle progression and induction of inflammation and senescence. By comparing responses to X-rays and Fe ion, radiation impact was found to be dependent on radiation quality, with a more pronounced and longer lasting response to Fe ions. Altogether, our data provide new molecular information on the causes of radiation-induced CVD and a basis on which to build new knowledge in order to ameliorate the current radiation protection system.

Details

Original languageEnglish
QualificationDoctor of Science
Supervisors/Advisors
  • Aerts, An, Supervisor
  • Sonveaux, Pierre, Supervisor, External person
Award date31 Aug 2017
Publication statusPublished - 30 Aug 2017

Keywords

  • molecular, Characterisation, endothelial cell response, radioation-induced atherosclerosis

ID: 3029305