Out‑of‑field effects: lessons learned from partial body exposure

Research output: Contribution to journalArticlepeer-review

Authors

  • Simonetta Pazzaglia
  • Markus Eidemüller
  • Katalin Lumniczky
  • Mariateresa Mancuso
  • Raghda Ramadan
  • Liliana Stolarczyk
  • Simone Moertl

Institutes & Expert groups

  • ENEA - Italian National Agency for New Technologies
  • GSF - HelmholtzZentrum München
  • National Public Health Center
  • Aarhus University Hospital
  • Bfs - Bundesamt Für Strahlenschutz - Federal Office for Radiation Protection

Documents & links

Abstract

Partial body exposure and inhomogeneous dose delivery are features of the majority of medical and occupational exposure situations. However, mounting evidence indicates that the effects of partial body exposure are not limited to the irradiated area but also have systemic effects that are propagated outside the irradiated field. It was the aim of the “Partial body exposure” session within the MELODI workshop 2020 to discuss recent developments and insights into this field by covering clinical, epidemiological, dosimetric as well as mechanistic aspects. Especially the impact of out-of-field effects on dysfunctions of immune cells, cardiovascular diseases and effects on the brain were debated. The presentations at the workshop acknowledged the relevance of out-of-field effects as components of the cellular and organismal radiation response. Furthermore, their importance for the understanding of radiation-induced pathologies, for the discovery of early disease biomarkers and for the identification of high-risk organs after inhomogeneous exposure was emphasized. With the rapid advancement of clinical treatment modalities, including new dose rates and distributions a better understanding of individual health risk is urgently needed. To achieve this, a deeper mechanistic understanding of out-of-field effects in close connection to improved modelling was suggested as priorities for future research. This will support the amelioration of risk models and the personalization of risk assessments for cancer and non-cancer effects after partial body irradiation.

Details

Original languageEnglish
Pages (from-to)1-20
Number of pages20
JournalRadiation and Environmental Biophysics
DOIs
Publication statusPublished - 3 Aug 2022

Keywords

  • Cardiovascular disease, Extracellular vesicles, Brain, Radiation dosimetry, Out-of-field d, Systemic radiation effects, Immune cel, Secondary cancer

ID: 7938831