Out‑of‑field effects: lessons learned from partial body exposure

Research output: Contribution to journalArticlepeer-review

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Out‑of‑field effects: lessons learned from partial body exposure. / Pazzaglia, Simonetta; Eidemüller, Markus; Lumniczky, Katalin; Mancuso, Mariateresa; Ramadan, Raghda; Stolarczyk, Liliana; Moertl, Simone.

In: Radiation and Environmental Biophysics, 03.08.2022, p. 1-20.

Research output: Contribution to journalArticlepeer-review

Harvard

Pazzaglia, S, Eidemüller, M, Lumniczky, K, Mancuso, M, Ramadan, R, Stolarczyk, L & Moertl, S 2022, 'Out‑of‑field effects: lessons learned from partial body exposure', Radiation and Environmental Biophysics, pp. 1-20. https://doi.org/10.1007/s00411-022-00988-0

APA

Pazzaglia, S., Eidemüller, M., Lumniczky, K., Mancuso, M., Ramadan, R., Stolarczyk, L., & Moertl, S. (2022). Out‑of‑field effects: lessons learned from partial body exposure. Radiation and Environmental Biophysics, 1-20. https://doi.org/10.1007/s00411-022-00988-0

Vancouver

Pazzaglia S, Eidemüller M, Lumniczky K, Mancuso M, Ramadan R, Stolarczyk L et al. Out‑of‑field effects: lessons learned from partial body exposure. Radiation and Environmental Biophysics. 2022 Aug 3;1-20. https://doi.org/10.1007/s00411-022-00988-0

Author

Pazzaglia, Simonetta ; Eidemüller, Markus ; Lumniczky, Katalin ; Mancuso, Mariateresa ; Ramadan, Raghda ; Stolarczyk, Liliana ; Moertl, Simone. / Out‑of‑field effects: lessons learned from partial body exposure. In: Radiation and Environmental Biophysics. 2022 ; pp. 1-20.

Bibtex - Download

@article{fade1b4cc9a746d483a46c1daa7ed13c,
title = "Out‑of‑field effects: lessons learned from partial body exposure",
abstract = "Partial body exposure and inhomogeneous dose delivery are features of the majority of medical and occupational exposure situations. However, mounting evidence indicates that the effects of partial body exposure are not limited to the irradiated area but also have systemic effects that are propagated outside the irradiated field. It was the aim of the “Partial body exposure” session within the MELODI workshop 2020 to discuss recent developments and insights into this field by covering clinical, epidemiological, dosimetric as well as mechanistic aspects. Especially the impact of out-of-field effects on dysfunctions of immune cells, cardiovascular diseases and effects on the brain were debated. The presentations at the workshop acknowledged the relevance of out-of-field effects as components of the cellular and organismal radiation response. Furthermore, their importance for the understanding of radiation-induced pathologies, for the discovery of early disease biomarkers and for the identification of high-risk organs after inhomogeneous exposure was emphasized. With the rapid advancement of clinical treatment modalities, including new dose rates and distributions a better understanding of individual health risk is urgently needed. To achieve this, a deeper mechanistic understanding of out-of-field effects in close connection to improved modelling was suggested as priorities for future research. This will support the amelioration of risk models and the personalization of risk assessments for cancer and non-cancer effects after partial body irradiation.",
keywords = "Cardiovascular disease, Extracellular vesicles, Brain, Radiation dosimetry, Out-of-field d, Systemic radiation effects, Immune cel, Secondary cancer",
author = "Simonetta Pazzaglia and Markus Eidem{\"u}ller and Katalin Lumniczky and Mariateresa Mancuso and Raghda Ramadan and Liliana Stolarczyk and Simone Moertl",
note = "Score=10",
year = "2022",
month = aug,
day = "3",
doi = "10.1007/s00411-022-00988-0",
language = "English",
pages = "1--20",
journal = "Radiation and Environmental Biophysics",
issn = "0301-634X",
publisher = "Springer",

}

RIS - Download

TY - JOUR

T1 - Out‑of‑field effects: lessons learned from partial body exposure

AU - Pazzaglia, Simonetta

AU - Eidemüller, Markus

AU - Lumniczky, Katalin

AU - Mancuso, Mariateresa

AU - Ramadan, Raghda

AU - Stolarczyk, Liliana

AU - Moertl, Simone

N1 - Score=10

PY - 2022/8/3

Y1 - 2022/8/3

N2 - Partial body exposure and inhomogeneous dose delivery are features of the majority of medical and occupational exposure situations. However, mounting evidence indicates that the effects of partial body exposure are not limited to the irradiated area but also have systemic effects that are propagated outside the irradiated field. It was the aim of the “Partial body exposure” session within the MELODI workshop 2020 to discuss recent developments and insights into this field by covering clinical, epidemiological, dosimetric as well as mechanistic aspects. Especially the impact of out-of-field effects on dysfunctions of immune cells, cardiovascular diseases and effects on the brain were debated. The presentations at the workshop acknowledged the relevance of out-of-field effects as components of the cellular and organismal radiation response. Furthermore, their importance for the understanding of radiation-induced pathologies, for the discovery of early disease biomarkers and for the identification of high-risk organs after inhomogeneous exposure was emphasized. With the rapid advancement of clinical treatment modalities, including new dose rates and distributions a better understanding of individual health risk is urgently needed. To achieve this, a deeper mechanistic understanding of out-of-field effects in close connection to improved modelling was suggested as priorities for future research. This will support the amelioration of risk models and the personalization of risk assessments for cancer and non-cancer effects after partial body irradiation.

AB - Partial body exposure and inhomogeneous dose delivery are features of the majority of medical and occupational exposure situations. However, mounting evidence indicates that the effects of partial body exposure are not limited to the irradiated area but also have systemic effects that are propagated outside the irradiated field. It was the aim of the “Partial body exposure” session within the MELODI workshop 2020 to discuss recent developments and insights into this field by covering clinical, epidemiological, dosimetric as well as mechanistic aspects. Especially the impact of out-of-field effects on dysfunctions of immune cells, cardiovascular diseases and effects on the brain were debated. The presentations at the workshop acknowledged the relevance of out-of-field effects as components of the cellular and organismal radiation response. Furthermore, their importance for the understanding of radiation-induced pathologies, for the discovery of early disease biomarkers and for the identification of high-risk organs after inhomogeneous exposure was emphasized. With the rapid advancement of clinical treatment modalities, including new dose rates and distributions a better understanding of individual health risk is urgently needed. To achieve this, a deeper mechanistic understanding of out-of-field effects in close connection to improved modelling was suggested as priorities for future research. This will support the amelioration of risk models and the personalization of risk assessments for cancer and non-cancer effects after partial body irradiation.

KW - Cardiovascular disease

KW - Extracellular vesicles

KW - Brain

KW - Radiation dosimetry

KW - Out-of-field d

KW - Systemic radiation effects

KW - Immune cel

KW - Secondary cancer

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/overview/50723166

U2 - 10.1007/s00411-022-00988-0

DO - 10.1007/s00411-022-00988-0

M3 - Article

SP - 1

EP - 20

JO - Radiation and Environmental Biophysics

JF - Radiation and Environmental Biophysics

SN - 0301-634X

ER -

ID: 7938831