Pathological effects of ionizing radiation: endothelial activation and dysfunction

Research output: Contribution to journalArticle

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Institutes & Expert groups

  • UCL - Université catholique de Louvain

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Abstract

The endothelium, a tissue that forms a single layer of cells lining various organs and cavities of the body, especially the heart and blood as well as lymphatic vessels, plays a complex role in vascular biology. It contributes to key aspects of vascular homeostasis and is also involved in pathophysiological processes, such as thrombosis, inflammation, and hypertension. Epidemiological data show that high doses of ionizing radiation lead to cardiovascular disease over time. The aim of this review is to summarize the current knowledge on endothelial cell activation and dysfunction after ionizing radiation exposure as a central feature preceding the development of cardiovascular diseases.

Details

Original languageEnglish
Pages (from-to)1-30
Number of pages30
JournalCellular and Molecular Life Science
Publication statusPublished - 30 Oct 2018

Keywords

  • Vascular tone, Procoagulation, prothtombosis, Endothelial cell retrraction, Mitochondrial dysfunction, Premature senescence

ID: 4753188