Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization

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Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization. / Vanreusel, Verdi; Gasparini, Alessia; Galante, Federica; Mariani, Giulia; Pacitti, Matteo; Cociorb, Madalina; Giammanco, Andrea; Reniers, Brigitte; Reulens, Nathalie; Shonde, Tunde Blessed; Vallet, Hugo; Vandenbroucke, Dirk; Peeters, Marc; Leblans, Paul; Ma, Biwu; Felici, Giuseppe; Verellen, Dirk; de Freitas Nascimento, Luana.

In: Physica Medica, Vol. 103, 11.2022, p. 127-137.

Research output: Contribution to journalArticlepeer-review

Harvard

Vanreusel, V, Gasparini, A, Galante, F, Mariani, G, Pacitti, M, Cociorb, M, Giammanco, A, Reniers, B, Reulens, N, Shonde, TB, Vallet, H, Vandenbroucke, D, Peeters, M, Leblans, P, Ma, B, Felici, G, Verellen, D & de Freitas Nascimento, L 2022, 'Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization', Physica Medica, vol. 103, pp. 127-137. https://doi.org/10.1016/j.ejmp.2022.10.005

APA

Vanreusel, V., Gasparini, A., Galante, F., Mariani, G., Pacitti, M., Cociorb, M., Giammanco, A., Reniers, B., Reulens, N., Shonde, T. B., Vallet, H., Vandenbroucke, D., Peeters, M., Leblans, P., Ma, B., Felici, G., Verellen, D., & de Freitas Nascimento, L. (2022). Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization. Physica Medica, 103, 127-137. https://doi.org/10.1016/j.ejmp.2022.10.005

Vancouver

Vanreusel V, Gasparini A, Galante F, Mariani G, Pacitti M, Cociorb M et al. Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization. Physica Medica. 2022 Nov;103:127-137. https://doi.org/10.1016/j.ejmp.2022.10.005

Author

Vanreusel, Verdi ; Gasparini, Alessia ; Galante, Federica ; Mariani, Giulia ; Pacitti, Matteo ; Cociorb, Madalina ; Giammanco, Andrea ; Reniers, Brigitte ; Reulens, Nathalie ; Shonde, Tunde Blessed ; Vallet, Hugo ; Vandenbroucke, Dirk ; Peeters, Marc ; Leblans, Paul ; Ma, Biwu ; Felici, Giuseppe ; Verellen, Dirk ; de Freitas Nascimento, Luana. / Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization. In: Physica Medica. 2022 ; Vol. 103. pp. 127-137.

Bibtex - Download

@article{48124cd57d6b4fa78182de01ab20ba58,
title = "Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization",
abstract = "FLASH radiation therapy is a novel technique combining ultra-high dose rates (UHDR) with very short treatment times to strongly decrease normal tissue toxicity while preserving the anti-tumoral effect. However, the radiobiological mechanisms and exact conditions for obtaining the FLASH-effect are still under investigation. There are strong indications that parameters defining the beam structure, such as dose per pulse, instantaneous dose rate and pulse repetition frequency (PRF) are of importance. UHDR irradiations therefore come with dosimetric challenges, including both dose assessment and temporal ones. In this work, a first characterization of 6 real-time point scintillating dosimeters with 5 phosphors (AlO:C,Mg; YO:Eu; AlO:C; (C38H34P)MnBr and (C38H34P)MnCl, was performed in an UHDR pulsed electron beam. The dose rate independence of the calibration was tested by calibrating the detector at conventional and UHDR. Dose rate dependence was observed, however, further investigation, including intermediate dose rates, is needed. Linearity of the response with dose was tested by varying the number of pulses and a linearity with R 0.9989 was observed up to at least 200 Gy. Dose per pulse linearity was investigated by variation of the pulse length and SSD. All point scintillators showed saturation effects up to some extent and the instantaneous dose rate dependence was confirmed. A PRF dependence was observed for the AlO:C,Mg and AlO:C- based point scintillators. This was expected as the luminescence decay time of these materials exceeds the inter-pulse time.",
keywords = "FLASH-RT, Point scintillators, Radioluminescence, Real-time dosimetry",
author = "Verdi Vanreusel and Alessia Gasparini and Federica Galante and Giulia Mariani and Matteo Pacitti and Madalina Cociorb and Andrea Giammanco and Brigitte Reniers and Nathalie Reulens and Shonde, {Tunde Blessed} and Hugo Vallet and Dirk Vandenbroucke and Marc Peeters and Paul Leblans and Biwu Ma and Giuseppe Felici and Dirk Verellen and {de Freitas Nascimento}, Luana",
note = "Score=10",
year = "2022",
month = nov,
doi = "10.1016/j.ejmp.2022.10.005",
language = "English",
volume = "103",
pages = "127--137",
journal = "Physica Medica",
issn = "1120-1797",
publisher = "Elsevier",

}

RIS - Download

TY - JOUR

T1 - Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy: A first characterization

AU - Vanreusel, Verdi

AU - Gasparini, Alessia

AU - Galante, Federica

AU - Mariani, Giulia

AU - Pacitti, Matteo

AU - Cociorb, Madalina

AU - Giammanco, Andrea

AU - Reniers, Brigitte

AU - Reulens, Nathalie

AU - Shonde, Tunde Blessed

AU - Vallet, Hugo

AU - Vandenbroucke, Dirk

AU - Peeters, Marc

AU - Leblans, Paul

AU - Ma, Biwu

AU - Felici, Giuseppe

AU - Verellen, Dirk

AU - de Freitas Nascimento, Luana

N1 - Score=10

PY - 2022/11

Y1 - 2022/11

N2 - FLASH radiation therapy is a novel technique combining ultra-high dose rates (UHDR) with very short treatment times to strongly decrease normal tissue toxicity while preserving the anti-tumoral effect. However, the radiobiological mechanisms and exact conditions for obtaining the FLASH-effect are still under investigation. There are strong indications that parameters defining the beam structure, such as dose per pulse, instantaneous dose rate and pulse repetition frequency (PRF) are of importance. UHDR irradiations therefore come with dosimetric challenges, including both dose assessment and temporal ones. In this work, a first characterization of 6 real-time point scintillating dosimeters with 5 phosphors (AlO:C,Mg; YO:Eu; AlO:C; (C38H34P)MnBr and (C38H34P)MnCl, was performed in an UHDR pulsed electron beam. The dose rate independence of the calibration was tested by calibrating the detector at conventional and UHDR. Dose rate dependence was observed, however, further investigation, including intermediate dose rates, is needed. Linearity of the response with dose was tested by varying the number of pulses and a linearity with R 0.9989 was observed up to at least 200 Gy. Dose per pulse linearity was investigated by variation of the pulse length and SSD. All point scintillators showed saturation effects up to some extent and the instantaneous dose rate dependence was confirmed. A PRF dependence was observed for the AlO:C,Mg and AlO:C- based point scintillators. This was expected as the luminescence decay time of these materials exceeds the inter-pulse time.

AB - FLASH radiation therapy is a novel technique combining ultra-high dose rates (UHDR) with very short treatment times to strongly decrease normal tissue toxicity while preserving the anti-tumoral effect. However, the radiobiological mechanisms and exact conditions for obtaining the FLASH-effect are still under investigation. There are strong indications that parameters defining the beam structure, such as dose per pulse, instantaneous dose rate and pulse repetition frequency (PRF) are of importance. UHDR irradiations therefore come with dosimetric challenges, including both dose assessment and temporal ones. In this work, a first characterization of 6 real-time point scintillating dosimeters with 5 phosphors (AlO:C,Mg; YO:Eu; AlO:C; (C38H34P)MnBr and (C38H34P)MnCl, was performed in an UHDR pulsed electron beam. The dose rate independence of the calibration was tested by calibrating the detector at conventional and UHDR. Dose rate dependence was observed, however, further investigation, including intermediate dose rates, is needed. Linearity of the response with dose was tested by varying the number of pulses and a linearity with R 0.9989 was observed up to at least 200 Gy. Dose per pulse linearity was investigated by variation of the pulse length and SSD. All point scintillators showed saturation effects up to some extent and the instantaneous dose rate dependence was confirmed. A PRF dependence was observed for the AlO:C,Mg and AlO:C- based point scintillators. This was expected as the luminescence decay time of these materials exceeds the inter-pulse time.

KW - FLASH-RT

KW - Point scintillators

KW - Radioluminescence

KW - Real-time dosimetry

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/overview/52005655

U2 - 10.1016/j.ejmp.2022.10.005

DO - 10.1016/j.ejmp.2022.10.005

M3 - Article

VL - 103

SP - 127

EP - 137

JO - Physica Medica

JF - Physica Medica

SN - 1120-1797

ER -

ID: 8170805