Production of Sn-117m in the BR2 high-flux reactor

Research output: Contribution to journalArticlepeer-review


  • Bernard Ponsard
  • Suresh C. Srivastava
  • Leonard F. Mausner
  • Russ F.F. Knapp
  • Marc A. Garland
  • Saed Mirzadeh
  • BNL - Brookhaven National Laboratory
  • ORNL - Oak Ridge National Laboratory

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The BR2 reactor is a 100 MWth high-flux ‘materials testing reactor’, which produces a wide range of radioisotopes for various applications in nuclear medicine and industry. Tin-117m (117mSn), a promising radionuclide for therapeutic applications, and its production have been validated in the BR2 reactor. In contrast to therapeutic beta emitters, 117mSn decays via isomeric transition with the emission of monoenergetic conversion electrons which are effective for metastatic bone pain palliation and radiosynovectomy with lesser damage to the bone marrow and the healthy tissues. Furthermore, the emitted gamma photons are ideal for imaging and dosimetry.


Original languageEnglish
Pages (from-to)1158-1161
Number of pages4
JournalApplied Radiation and Isotopes
Issue number7-8
Publication statusPublished - 1 Jul 2009


  • BR2 high-flux reactor, Medical isotopes, 117mSn, Bone pain palliation, Radiosynovectomy

ID: 6833873