Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scans

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Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scans. / Belmans, Niels; Gilles, Liese; Vermeesen, Randy; Piroska, Virag; Hedisu, Mihaela; Salmon, Benjamin; Baatout, Sarah; Lucas, Stéphane; Lambrichts, Ivo; Jacobs, Reinhilde; Moreels, Marjan.

In: Scientific Reports, 07.02.2020, p. 1-13.

Research output: Contribution to journalArticlepeer-review

Harvard

Belmans, N, Gilles, L, Vermeesen, R, Piroska, V, Hedisu, M, Salmon, B, Baatout, S, Lucas, S, Lambrichts, I, Jacobs, R & Moreels, M 2020, 'Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scans', Scientific Reports, pp. 1-13. https://doi.org/10.1038/s41598-020-58746-5

APA

Belmans, N., Gilles, L., Vermeesen, R., Piroska, V., Hedisu, M., Salmon, B., Baatout, S., Lucas, S., Lambrichts, I., Jacobs, R., & Moreels, M. (2020). Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scans. Scientific Reports, 1-13. https://doi.org/10.1038/s41598-020-58746-5

Author

Belmans, Niels ; Gilles, Liese ; Vermeesen, Randy ; Piroska, Virag ; Hedisu, Mihaela ; Salmon, Benjamin ; Baatout, Sarah ; Lucas, Stéphane ; Lambrichts, Ivo ; Jacobs, Reinhilde ; Moreels, Marjan. / Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scans. In: Scientific Reports. 2020 ; pp. 1-13.

Bibtex - Download

@article{2effc1b371c64c2b9a71888a8568bb54,
title = "Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scans",
abstract = "Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.",
keywords = "DNA damage response, Three-dimensional imaging, Biomarkers",
author = "Niels Belmans and Liese Gilles and Randy Vermeesen and Virag Piroska and Mihaela Hedisu and Benjamin Salmon and Sarah Baatout and St{\'e}phane Lucas and Ivo Lambrichts and Reinhilde Jacobs and Marjan Moreels",
note = "Score=10",
year = "2020",
month = feb,
day = "7",
doi = "10.1038/s41598-020-58746-5",
language = "English",
pages = "1--13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS - Download

TY - JOUR

T1 - Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scans

AU - Belmans, Niels

AU - Gilles, Liese

AU - Vermeesen, Randy

AU - Piroska, Virag

AU - Hedisu, Mihaela

AU - Salmon, Benjamin

AU - Baatout, Sarah

AU - Lucas, Stéphane

AU - Lambrichts, Ivo

AU - Jacobs, Reinhilde

AU - Moreels, Marjan

N1 - Score=10

PY - 2020/2/7

Y1 - 2020/2/7

N2 - Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.

AB - Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.

KW - DNA damage response

KW - Three-dimensional imaging

KW - Biomarkers

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/37343590

U2 - 10.1038/s41598-020-58746-5

DO - 10.1038/s41598-020-58746-5

M3 - Article

SP - 1

EP - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

ER -

ID: 6375839