Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?

Research output: Contribution to journalLiterature review

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  • UA - Universiteit Antwerpen

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Abstract

Radiotherapy in cancer treatment involves the use of ionizing radiation for cancer cell killing. Although radiotherapy has shown significant improvements on cancer recurrence and mortality, several radiation-induced adverse effects have been documented. Of these adverse effects, radiation-induced cardiovascular disease (CVD) is particularly prominent among patients receiving mediastinal radiotherapy, such as breast cancer and Hodgkin’s lymphoma patients. A number of mechanisms of radiation-induced CVD pathogenesis have been proposed such as endothelial inflammatory activation, premature endothelial senescence, increased ROS and mitochondrial dysfunction. However, current research seems to point to a so-far unexamined and potentially novel involvement of epigenetics in radiation-induced CVD pathogenesis. Firstly, epigenetic mechanisms have been implicated in CVD pathophysiology. In addition, several studies have shown that ionizing radiation can cause epigenetic modifications, especially DNA methylation alterations. As a result, this review aims to provide a summary of the current literature linking DNA methylation to radiation-induced CVD and thereby explore DNA methylation as a possible contributor to radiation-induced CVD pathogenesis.

Details

Original languageEnglish
Pages (from-to)1-23
Number of pages23
JournalEpigenetics
DOIs
Publication statusPublished - 31 Jan 2021

Keywords

  • Radiation, Cardiovascular disease, Epigenetics, DNA methylation, Breast cancer

ID: 7164460