Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?

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Radiation-induced cardiovascular disease: an overlooked role for DNA methylation? / Sallam, Magy; Benotmane, Rafi; Baatout, Sarah; Guns, Pieter-Jan; Aerts, An.

In: Epigenetics, 31.01.2021, p. 1-23.

Research output: Contribution to journalLiterature reviewpeer-review

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@article{20ece4aa9faa465fa6c67dba2eaf7853,
title = "Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?",
abstract = "Radiotherapy in cancer treatment involves the use of ionizing radiation for cancer cell killing. Although radiotherapy has shown significant improvements on cancer recurrence and mortality, several radiation-induced adverse effects have been documented. Of these adverse effects, radiation-induced cardiovascular disease (CVD) is particularly prominent among patients receiving mediastinal radiotherapy, such as breast cancer and Hodgkin{\textquoteright}s lymphoma patients. A number of mechanisms of radiation-induced CVD pathogenesis have been proposed such as endothelial inflammatory activation, premature endothelial senescence, increased ROS and mitochondrial dysfunction. However, current research seems to point to a so-far unexamined and potentially novel involvement of epigenetics in radiation-induced CVD pathogenesis. Firstly, epigenetic mechanisms have been implicated in CVD pathophysiology. In addition, several studies have shown that ionizing radiation can cause epigenetic modifications, especially DNA methylation alterations. As a result, this review aims to provide a summary of the current literature linking DNA methylation to radiation-induced CVD and thereby explore DNA methylation as a possible contributor to radiation-induced CVD pathogenesis.",
keywords = "Radiation, Cardiovascular disease, Epigenetics, DNA methylation, Breast cancer",
author = "Magy Sallam and Rafi Benotmane and Sarah Baatout and Pieter-Jan Guns and An Aerts",
note = "Score=10",
year = "2021",
month = jan,
day = "31",
doi = "10.1080/15592294.2021.1873628",
language = "English",
pages = "1--23",
journal = "Epigenetics",
issn = "1559-2308",
publisher = "Taylor & Francis (CRC)",

}

RIS - Download

TY - JOUR

T1 - Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?

AU - Sallam, Magy

AU - Benotmane, Rafi

AU - Baatout, Sarah

AU - Guns, Pieter-Jan

AU - Aerts, An

N1 - Score=10

PY - 2021/1/31

Y1 - 2021/1/31

N2 - Radiotherapy in cancer treatment involves the use of ionizing radiation for cancer cell killing. Although radiotherapy has shown significant improvements on cancer recurrence and mortality, several radiation-induced adverse effects have been documented. Of these adverse effects, radiation-induced cardiovascular disease (CVD) is particularly prominent among patients receiving mediastinal radiotherapy, such as breast cancer and Hodgkin’s lymphoma patients. A number of mechanisms of radiation-induced CVD pathogenesis have been proposed such as endothelial inflammatory activation, premature endothelial senescence, increased ROS and mitochondrial dysfunction. However, current research seems to point to a so-far unexamined and potentially novel involvement of epigenetics in radiation-induced CVD pathogenesis. Firstly, epigenetic mechanisms have been implicated in CVD pathophysiology. In addition, several studies have shown that ionizing radiation can cause epigenetic modifications, especially DNA methylation alterations. As a result, this review aims to provide a summary of the current literature linking DNA methylation to radiation-induced CVD and thereby explore DNA methylation as a possible contributor to radiation-induced CVD pathogenesis.

AB - Radiotherapy in cancer treatment involves the use of ionizing radiation for cancer cell killing. Although radiotherapy has shown significant improvements on cancer recurrence and mortality, several radiation-induced adverse effects have been documented. Of these adverse effects, radiation-induced cardiovascular disease (CVD) is particularly prominent among patients receiving mediastinal radiotherapy, such as breast cancer and Hodgkin’s lymphoma patients. A number of mechanisms of radiation-induced CVD pathogenesis have been proposed such as endothelial inflammatory activation, premature endothelial senescence, increased ROS and mitochondrial dysfunction. However, current research seems to point to a so-far unexamined and potentially novel involvement of epigenetics in radiation-induced CVD pathogenesis. Firstly, epigenetic mechanisms have been implicated in CVD pathophysiology. In addition, several studies have shown that ionizing radiation can cause epigenetic modifications, especially DNA methylation alterations. As a result, this review aims to provide a summary of the current literature linking DNA methylation to radiation-induced CVD and thereby explore DNA methylation as a possible contributor to radiation-induced CVD pathogenesis.

KW - Radiation

KW - Cardiovascular disease

KW - Epigenetics

KW - DNA methylation

KW - Breast cancer

UR - https://ecm.sckcen.be/OTCS/llisapi.dll?func=ll&objAction=download&objId=44877716

U2 - 10.1080/15592294.2021.1873628

DO - 10.1080/15592294.2021.1873628

M3 - Literature review

SP - 1

EP - 23

JO - Epigenetics

JF - Epigenetics

SN - 1559-2308

ER -

ID: 7164460