Radiation-induced cardiovascular risks: Cardiovascular effects related to low doses of ionizing radiation; endothelial response after low dose X-irradiation, focusing on oxidative stress and mitochondrial DNA damage.

Research output: ThesisMaster's thesis

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@phdthesis{0d554bc2558949bcbef07b178bc61d70,
title = "Radiation-induced cardiovascular risks: Cardiovascular effects related to low doses of ionizing radiation; endothelial response after low dose X-irradiation, focusing on oxidative stress and mitochondrial DNA damage.",
abstract = "The current radiation protection system is based on the assumption that there is a threshold of low dose radiation below which no significant non-cancer effects are observed. However, recent epidemiological evidence points to an excess risk of late occurring cardiovascular diseases at much lower radiation doses and after longer time intervals than previously thought. Since these epidemiological data lack statistical power, additional evidence has to come from experimental data. The endothelium is considered as a critical target in the development of radiation-related cardiovascular diseases. In the current project, the effects of acute and fractionated low and medium dose radiation (0.05 -5Gy) have been investigated on endothelial cells (EA.hy926) in vitro. In particular, different endpoints that play a role in the inception and further development of atherosclerosis were assessed by X-irradiation (acute radiation) for detecting Reactive Oxygen Species and Mitochondrial DNA damage (common deletion). In addition, fractionated radiation was done in order to assess nuclear DNA damage and apoptosis in endothelial cells. Therefore, this project could contribute to a better radiation protection system.",
keywords = "EA.hy926, Reactive Oxygen Species, Apoptosis, Common deletion, Nuclear damage. X-rays",
author = "{Talavera Moreno}, Nerea and Charlotte Rombouts",
note = "Score = 2",
year = "2013",
month = "6",
day = "13",
language = "English",
publisher = "UPV - Universitat Polit{\`e}cnica de Val{\`e}ncia",
school = "UPV - University Polytechnic of Valencia, UGent - Universiteit Gent",

}

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TY - THES

T1 - Radiation-induced cardiovascular risks: Cardiovascular effects related to low doses of ionizing radiation; endothelial response after low dose X-irradiation, focusing on oxidative stress and mitochondrial DNA damage.

AU - Talavera Moreno, Nerea

A2 - Rombouts, Charlotte

N1 - Score = 2

PY - 2013/6/13

Y1 - 2013/6/13

N2 - The current radiation protection system is based on the assumption that there is a threshold of low dose radiation below which no significant non-cancer effects are observed. However, recent epidemiological evidence points to an excess risk of late occurring cardiovascular diseases at much lower radiation doses and after longer time intervals than previously thought. Since these epidemiological data lack statistical power, additional evidence has to come from experimental data. The endothelium is considered as a critical target in the development of radiation-related cardiovascular diseases. In the current project, the effects of acute and fractionated low and medium dose radiation (0.05 -5Gy) have been investigated on endothelial cells (EA.hy926) in vitro. In particular, different endpoints that play a role in the inception and further development of atherosclerosis were assessed by X-irradiation (acute radiation) for detecting Reactive Oxygen Species and Mitochondrial DNA damage (common deletion). In addition, fractionated radiation was done in order to assess nuclear DNA damage and apoptosis in endothelial cells. Therefore, this project could contribute to a better radiation protection system.

AB - The current radiation protection system is based on the assumption that there is a threshold of low dose radiation below which no significant non-cancer effects are observed. However, recent epidemiological evidence points to an excess risk of late occurring cardiovascular diseases at much lower radiation doses and after longer time intervals than previously thought. Since these epidemiological data lack statistical power, additional evidence has to come from experimental data. The endothelium is considered as a critical target in the development of radiation-related cardiovascular diseases. In the current project, the effects of acute and fractionated low and medium dose radiation (0.05 -5Gy) have been investigated on endothelial cells (EA.hy926) in vitro. In particular, different endpoints that play a role in the inception and further development of atherosclerosis were assessed by X-irradiation (acute radiation) for detecting Reactive Oxygen Species and Mitochondrial DNA damage (common deletion). In addition, fractionated radiation was done in order to assess nuclear DNA damage and apoptosis in endothelial cells. Therefore, this project could contribute to a better radiation protection system.

KW - EA.hy926

KW - Reactive Oxygen Species

KW - Apoptosis

KW - Common deletion

KW - Nuclear damage. X-rays

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_129766

M3 - Master's thesis

PB - UPV - Universitat Politècnica de València

CY - Gent, Belgium

ER -

ID: 181956