Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system

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Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. / Abouelaradat, Khalil; Derradji, Hanane; De Vos, Winnok; De Meyer, Tim; Bekaert, Sofie; Van Criekinge, Wim; Baatout, Sarah.

In: International Journal of Oncology, Vol. 39, No. 6, 29.08.2011, p. 1429-1441.

Research output: Contribution to journalArticle

Harvard

Abouelaradat, K, Derradji, H, De Vos, W, De Meyer, T, Bekaert, S, Van Criekinge, W & Baatout, S 2011, 'Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system', International Journal of Oncology, vol. 39, no. 6, pp. 1429-1441. https://doi.org/10.3892/ijo.2011.1175

APA

Abouelaradat, K., Derradji, H., De Vos, W., De Meyer, T., Bekaert, S., Van Criekinge, W., & Baatout, S. (2011). Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. International Journal of Oncology, 39(6), 1429-1441. https://doi.org/10.3892/ijo.2011.1175

Vancouver

Abouelaradat K, Derradji H, De Vos W, De Meyer T, Bekaert S, Van Criekinge W et al. Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. International Journal of Oncology. 2011 Aug 29;39(6):1429-1441. https://doi.org/10.3892/ijo.2011.1175

Author

Abouelaradat, Khalil ; Derradji, Hanane ; De Vos, Winnok ; De Meyer, Tim ; Bekaert, Sofie ; Van Criekinge, Wim ; Baatout, Sarah. / Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. In: International Journal of Oncology. 2011 ; Vol. 39, No. 6. pp. 1429-1441.

Bibtex - Download

@article{e732c1c131fe474eabff75468da57ff3,
title = "Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system",
abstract = "The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investi-gated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 cells in the S phase, but not in the number of BCPAP p53-mutant cells. At a dose of 0.5 Gy, visible signs of senescence appeared only in the TPC-1 cells. We conclude that low doses of X-rays are enough to cause a change in cell cycle distribution, possibly p53-dependent p16 activation, but no significant apoptosis. Senescence requires higher doses of X-irradiation via a mechanism involving both p16 and p21",
keywords = "TPC-1, Papillary thyroid carcinoma, RET/PTC, p53",
author = "Khalil Abouelaradat and Hanane Derradji and {De Vos}, Winnok and {De Meyer}, Tim and Sofie Bekaert and {Van Criekinge}, Wim and Sarah Baatout",
note = "Score = 10",
year = "2011",
month = "8",
day = "29",
doi = "10.3892/ijo.2011.1175",
language = "English",
volume = "39",
pages = "1429--1441",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "6",

}

RIS - Download

TY - JOUR

T1 - Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system

AU - Abouelaradat, Khalil

AU - Derradji, Hanane

AU - De Vos, Winnok

AU - De Meyer, Tim

AU - Bekaert, Sofie

AU - Van Criekinge, Wim

AU - Baatout, Sarah

N1 - Score = 10

PY - 2011/8/29

Y1 - 2011/8/29

N2 - The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investi-gated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 cells in the S phase, but not in the number of BCPAP p53-mutant cells. At a dose of 0.5 Gy, visible signs of senescence appeared only in the TPC-1 cells. We conclude that low doses of X-rays are enough to cause a change in cell cycle distribution, possibly p53-dependent p16 activation, but no significant apoptosis. Senescence requires higher doses of X-irradiation via a mechanism involving both p16 and p21

AB - The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investi-gated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 cells in the S phase, but not in the number of BCPAP p53-mutant cells. At a dose of 0.5 Gy, visible signs of senescence appeared only in the TPC-1 cells. We conclude that low doses of X-rays are enough to cause a change in cell cycle distribution, possibly p53-dependent p16 activation, but no significant apoptosis. Senescence requires higher doses of X-irradiation via a mechanism involving both p16 and p21

KW - TPC-1

KW - Papillary thyroid carcinoma

KW - RET/PTC

KW - p53

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_115597

UR - http://knowledgecentre.sckcen.be/so2/bibref/8272

U2 - 10.3892/ijo.2011.1175

DO - 10.3892/ijo.2011.1175

M3 - Article

VL - 39

SP - 1429

EP - 1441

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 6

ER -

ID: 254298