Selected Endothelial Responses after Ionizing Radiation Exposure

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Selected Endothelial Responses after Ionizing Radiation Exposure. / Baselet, Bjorn; Ramadan, Raghda; Benotmane, Rafi; Baatout, Sarah; Aerts, An.

Endothelial dysfunction old concepts and new challenges. ed. / Helena Lenasi. InTech, 2018.

Research output: Contribution to report/book/conference proceedingsChapter

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Author

Baselet, Bjorn ; Ramadan, Raghda ; Benotmane, Rafi ; Baatout, Sarah ; Aerts, An. / Selected Endothelial Responses after Ionizing Radiation Exposure. Endothelial dysfunction old concepts and new challenges. editor / Helena Lenasi. InTech, 2018.

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@inbook{739433cdffef4fe68b150d856cb7070a,
title = "Selected Endothelial Responses after Ionizing Radiation Exposure",
abstract = "Along with the development of novel chemotherapeutic agents, radiation therapy has revolutionized the prognosis of patients with various cancers. However, with a longer life expectancy, radiation treatment-related comorbidity, like cardiovascular diseases (CVDs), becomes an issue for cancer survivors. In addition, exposure to X-rays for medical diagnostics is dramatically increasing at the present times. A pressing question is whether or not exposure to these very low doses can cause health damage. Below 0.5 gray (Gy), an increased risk cannot be evidenced by epidemiology alone, and in vitro and in vivo mechanistic studies focused on the elucidation of molecular signaling pathways are needed. Given the critical role of the endothelium in normal vascular functions, a complete understanding of radiation-induced endothelial dysfunction is crucial. In this way, the current radiation protection system could be refined if needed, making it possible to more accurately assess the cardiovascular risk in the low-dose region. Finally, radiation-induced CVD, like CVD in general, is a progressive disorder that may take years to decades to manifest. Therefore, experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential interventions—together with a healthy lifestyle—that may prevent or mitigate these adverse effects.",
keywords = "Endothelial cells, dysfunction, cardiovascular disease, ionizing radiation",
author = "Bjorn Baselet and Raghda Ramadan and Rafi Benotmane and Sarah Baatout and An Aerts",
note = "Score=10",
year = "2018",
month = "10",
day = "24",
doi = "10.5772/intechopen.72386",
language = "English",
isbn = "978-1-78984-253-1",
editor = "Helena Lenasi",
booktitle = "Endothelial dysfunction old concepts and new challenges",
publisher = "InTech",

}

RIS - Download

TY - CHAP

T1 - Selected Endothelial Responses after Ionizing Radiation Exposure

AU - Baselet, Bjorn

AU - Ramadan, Raghda

AU - Benotmane, Rafi

AU - Baatout, Sarah

AU - Aerts, An

N1 - Score=10

PY - 2018/10/24

Y1 - 2018/10/24

N2 - Along with the development of novel chemotherapeutic agents, radiation therapy has revolutionized the prognosis of patients with various cancers. However, with a longer life expectancy, radiation treatment-related comorbidity, like cardiovascular diseases (CVDs), becomes an issue for cancer survivors. In addition, exposure to X-rays for medical diagnostics is dramatically increasing at the present times. A pressing question is whether or not exposure to these very low doses can cause health damage. Below 0.5 gray (Gy), an increased risk cannot be evidenced by epidemiology alone, and in vitro and in vivo mechanistic studies focused on the elucidation of molecular signaling pathways are needed. Given the critical role of the endothelium in normal vascular functions, a complete understanding of radiation-induced endothelial dysfunction is crucial. In this way, the current radiation protection system could be refined if needed, making it possible to more accurately assess the cardiovascular risk in the low-dose region. Finally, radiation-induced CVD, like CVD in general, is a progressive disorder that may take years to decades to manifest. Therefore, experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential interventions—together with a healthy lifestyle—that may prevent or mitigate these adverse effects.

AB - Along with the development of novel chemotherapeutic agents, radiation therapy has revolutionized the prognosis of patients with various cancers. However, with a longer life expectancy, radiation treatment-related comorbidity, like cardiovascular diseases (CVDs), becomes an issue for cancer survivors. In addition, exposure to X-rays for medical diagnostics is dramatically increasing at the present times. A pressing question is whether or not exposure to these very low doses can cause health damage. Below 0.5 gray (Gy), an increased risk cannot be evidenced by epidemiology alone, and in vitro and in vivo mechanistic studies focused on the elucidation of molecular signaling pathways are needed. Given the critical role of the endothelium in normal vascular functions, a complete understanding of radiation-induced endothelial dysfunction is crucial. In this way, the current radiation protection system could be refined if needed, making it possible to more accurately assess the cardiovascular risk in the low-dose region. Finally, radiation-induced CVD, like CVD in general, is a progressive disorder that may take years to decades to manifest. Therefore, experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential interventions—together with a healthy lifestyle—that may prevent or mitigate these adverse effects.

KW - Endothelial cells

KW - dysfunction

KW - cardiovascular disease

KW - ionizing radiation

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/31474568

U2 - 10.5772/intechopen.72386

DO - 10.5772/intechopen.72386

M3 - Chapter

SN - 978-1-78984-253-1

BT - Endothelial dysfunction old concepts and new challenges

A2 - Lenasi, Helena

PB - InTech

ER -

ID: 4692144