Sensitivity of germ cells and embryos to ionizing radiation

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Sensitivity of germ cells and embryos to ionizing radiation. / Jacquet, Patrice.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 18, No. 2, 2004, p. 106-114.

Research output: Contribution to journalArticlepeer-review

Harvard

Jacquet, P 2004, 'Sensitivity of germ cells and embryos to ionizing radiation', Journal of Biological Regulators and Homeostatic Agents, vol. 18, no. 2, pp. 106-114.

APA

Jacquet, P. (2004). Sensitivity of germ cells and embryos to ionizing radiation. Journal of Biological Regulators and Homeostatic Agents, 18(2), 106-114.

Vancouver

Jacquet P. Sensitivity of germ cells and embryos to ionizing radiation. Journal of Biological Regulators and Homeostatic Agents. 2004;18(2):106-114.

Author

Jacquet, Patrice. / Sensitivity of germ cells and embryos to ionizing radiation. In: Journal of Biological Regulators and Homeostatic Agents. 2004 ; Vol. 18, No. 2. pp. 106-114.

Bibtex - Download

@article{1f9ead4c09b940c893cf4da1b93f2fc5,
title = "Sensitivity of germ cells and embryos to ionizing radiation",
abstract = "Experiments performed in laboratory animals suggest that ionizing radiation can induce DNA damage in the germ cells of exposed individuals and lead to various deleterious effects in their progeny, including miscarriage, low birth weight, congenital abnormalities and perhaps cancer. However, no clear evidence for such effects has been found in epidemiological studies of people exposed to radiation. The predicted risks of hereditary effects of any kinds resulting from parental exposure to relatively low doses of ionizing radiation remain very low, compared to the spontaneous risks in the absence of irradiation. Irradiation of the mouse embryo can lead to various effects (lethality, growth retardation, congenital abnormalities), depending on the period of gestation at which irradiation occurs. In humans, prenatal irradiation has only been exceptionally associated with congenital abnormalities, but irradiation between weeks 8-25 has been shown to be able to induce severe mental retardation. Although being not proven, the risk of developing a childhood cancer following prenatal irradiation may also not be excluded. Like for genetic effects, the risk of adverse effects following exposure of the embryo to relatively low doses remains quite low compared to the natural risks.",
keywords = "ionizing radiation, germ cells, embryos",
author = "Patrice Jacquet",
note = "Score=10",
year = "2004",
language = "English",
volume = "18",
pages = "106--114",
journal = "Journal of Biological Regulators and Homeostatic Agents",
issn = "0393-974X",
publisher = "Wichtig editore",
number = "2",

}

RIS - Download

TY - JOUR

T1 - Sensitivity of germ cells and embryos to ionizing radiation

AU - Jacquet, Patrice

N1 - Score=10

PY - 2004

Y1 - 2004

N2 - Experiments performed in laboratory animals suggest that ionizing radiation can induce DNA damage in the germ cells of exposed individuals and lead to various deleterious effects in their progeny, including miscarriage, low birth weight, congenital abnormalities and perhaps cancer. However, no clear evidence for such effects has been found in epidemiological studies of people exposed to radiation. The predicted risks of hereditary effects of any kinds resulting from parental exposure to relatively low doses of ionizing radiation remain very low, compared to the spontaneous risks in the absence of irradiation. Irradiation of the mouse embryo can lead to various effects (lethality, growth retardation, congenital abnormalities), depending on the period of gestation at which irradiation occurs. In humans, prenatal irradiation has only been exceptionally associated with congenital abnormalities, but irradiation between weeks 8-25 has been shown to be able to induce severe mental retardation. Although being not proven, the risk of developing a childhood cancer following prenatal irradiation may also not be excluded. Like for genetic effects, the risk of adverse effects following exposure of the embryo to relatively low doses remains quite low compared to the natural risks.

AB - Experiments performed in laboratory animals suggest that ionizing radiation can induce DNA damage in the germ cells of exposed individuals and lead to various deleterious effects in their progeny, including miscarriage, low birth weight, congenital abnormalities and perhaps cancer. However, no clear evidence for such effects has been found in epidemiological studies of people exposed to radiation. The predicted risks of hereditary effects of any kinds resulting from parental exposure to relatively low doses of ionizing radiation remain very low, compared to the spontaneous risks in the absence of irradiation. Irradiation of the mouse embryo can lead to various effects (lethality, growth retardation, congenital abnormalities), depending on the period of gestation at which irradiation occurs. In humans, prenatal irradiation has only been exceptionally associated with congenital abnormalities, but irradiation between weeks 8-25 has been shown to be able to induce severe mental retardation. Although being not proven, the risk of developing a childhood cancer following prenatal irradiation may also not be excluded. Like for genetic effects, the risk of adverse effects following exposure of the embryo to relatively low doses remains quite low compared to the natural risks.

KW - ionizing radiation

KW - germ cells

KW - embryos

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/axs_1147423

M3 - Article

VL - 18

SP - 106

EP - 114

JO - Journal of Biological Regulators and Homeostatic Agents

JF - Journal of Biological Regulators and Homeostatic Agents

SN - 0393-974X

IS - 2

ER -

ID: 3426441