SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field

Research output: Contribution to journalArticle

Standard

SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field. / Debrot, E.; Tran, L.; Chartier, J. L.; Bolst, D.; Guatelli, S.; Vandevoorde, C.; de Kock, E.; Beukes, Paul; Symons, J.; Nieto-Camero, J.; Prokopovich, D.A.; Chiriotti Alvarez, Sabina; Parisi, Alessio; De Saint-Hubert, Marijke; Vanhavere, Filip; Slabbert, J.; Rosenfeld, A.B.

In: Physics in Medicine and Biology, Vol. 63, 235007, 23.11.2018.

Research output: Contribution to journalArticle

Harvard

Debrot, E, Tran, L, Chartier, JL, Bolst, D, Guatelli, S, Vandevoorde, C, de Kock, E, Beukes, P, Symons, J, Nieto-Camero, J, Prokopovich, DA, Chiriotti Alvarez, S, Parisi, A, De Saint-Hubert, M, Vanhavere, F, Slabbert, J & Rosenfeld, AB 2018, 'SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field', Physics in Medicine and Biology, vol. 63, 235007. https://doi.org/10.1088/1361-6560/aaec2f/meta

APA

Debrot, E., Tran, L., Chartier, J. L., Bolst, D., Guatelli, S., Vandevoorde, C., ... Rosenfeld, A. B. (2018). SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field. Physics in Medicine and Biology, 63, [235007]. https://doi.org/10.1088/1361-6560/aaec2f/meta

Vancouver

Debrot E, Tran L, Chartier JL, Bolst D, Guatelli S, Vandevoorde C et al. SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field. Physics in Medicine and Biology. 2018 Nov 23;63. 235007. https://doi.org/10.1088/1361-6560/aaec2f/meta

Author

Debrot, E. ; Tran, L. ; Chartier, J. L. ; Bolst, D. ; Guatelli, S. ; Vandevoorde, C. ; de Kock, E. ; Beukes, Paul ; Symons, J. ; Nieto-Camero, J. ; Prokopovich, D.A. ; Chiriotti Alvarez, Sabina ; Parisi, Alessio ; De Saint-Hubert, Marijke ; Vanhavere, Filip ; Slabbert, J. ; Rosenfeld, A.B. / SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field. In: Physics in Medicine and Biology. 2018 ; Vol. 63.

Bibtex - Download

@article{80d8862c1c104310836344f8d11b6170,
title = "SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field",
abstract = "With more patients receiving external beam radiation therapy with protons, it becomes increasingly important to refine the clinical understanding of the relative biological effectiveness (RBE) for dose delivered during treatment. Treatment planning systems used in clinics typically implement a constant RBE of 1.1 for proton fields irrespective of their highly heterogeneous linear energy transfer (LET). Quality assurance tools that can measure beam characteristics and quantify or be indicative of biological outcomes become necessary in the transition towards more sophisticated RBE weighted treatment planning and for verification of the Monte Carlo and analytical based models they use. In this study the RBE for the CHO-K1 cell line in a passively delivered clinical proton spread out Bragg peak (SOBP) is determined both in vitro and using a silicon-on-insulator (SOI) microdosimetry method paired with the modified microdosimetric kinetic model. The RBE along the central axis of a SOBP with 2 Gy delivered at the middle of the treatment field was found to vary between 1.11–1.98 and the RBE for 10{\%} cell survival between 1.07–1.58 with a 250 kVp x-ray reference radiation and between 1.19–2.34 and 0.95–1.41, respectively, for a Co60 reference. Good agreement was found between RBE values calculated from the SOI-microdosimetry-MKM approach and in vitro. A strong correlation between proton lineal energy and RBE was observed particularly in the distal end and falloff of the SOBP.",
keywords = "proton therapy, RBE, microdosimetry, MKM",
author = "E. Debrot and L. Tran and Chartier, {J. L.} and D. Bolst and S. Guatelli and C. Vandevoorde and {de Kock}, E. and Paul Beukes and J. Symons and J. Nieto-Camero and D.A. Prokopovich and {Chiriotti Alvarez}, Sabina and Alessio Parisi and {De Saint-Hubert}, Marijke and Filip Vanhavere and J. Slabbert and A.B. Rosenfeld",
note = "Score=10",
year = "2018",
month = "11",
day = "23",
doi = "10.1088/1361-6560/aaec2f/meta",
language = "English",
volume = "63",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP - IOP Publishing",

}

RIS - Download

TY - JOUR

T1 - SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field

AU - Debrot, E.

AU - Tran, L.

AU - Chartier, J. L.

AU - Bolst, D.

AU - Guatelli, S.

AU - Vandevoorde, C.

AU - de Kock, E.

AU - Beukes, Paul

AU - Symons, J.

AU - Nieto-Camero, J.

AU - Prokopovich, D.A.

AU - Chiriotti Alvarez, Sabina

AU - Parisi, Alessio

AU - De Saint-Hubert, Marijke

AU - Vanhavere, Filip

AU - Slabbert, J.

AU - Rosenfeld, A.B.

N1 - Score=10

PY - 2018/11/23

Y1 - 2018/11/23

N2 - With more patients receiving external beam radiation therapy with protons, it becomes increasingly important to refine the clinical understanding of the relative biological effectiveness (RBE) for dose delivered during treatment. Treatment planning systems used in clinics typically implement a constant RBE of 1.1 for proton fields irrespective of their highly heterogeneous linear energy transfer (LET). Quality assurance tools that can measure beam characteristics and quantify or be indicative of biological outcomes become necessary in the transition towards more sophisticated RBE weighted treatment planning and for verification of the Monte Carlo and analytical based models they use. In this study the RBE for the CHO-K1 cell line in a passively delivered clinical proton spread out Bragg peak (SOBP) is determined both in vitro and using a silicon-on-insulator (SOI) microdosimetry method paired with the modified microdosimetric kinetic model. The RBE along the central axis of a SOBP with 2 Gy delivered at the middle of the treatment field was found to vary between 1.11–1.98 and the RBE for 10% cell survival between 1.07–1.58 with a 250 kVp x-ray reference radiation and between 1.19–2.34 and 0.95–1.41, respectively, for a Co60 reference. Good agreement was found between RBE values calculated from the SOI-microdosimetry-MKM approach and in vitro. A strong correlation between proton lineal energy and RBE was observed particularly in the distal end and falloff of the SOBP.

AB - With more patients receiving external beam radiation therapy with protons, it becomes increasingly important to refine the clinical understanding of the relative biological effectiveness (RBE) for dose delivered during treatment. Treatment planning systems used in clinics typically implement a constant RBE of 1.1 for proton fields irrespective of their highly heterogeneous linear energy transfer (LET). Quality assurance tools that can measure beam characteristics and quantify or be indicative of biological outcomes become necessary in the transition towards more sophisticated RBE weighted treatment planning and for verification of the Monte Carlo and analytical based models they use. In this study the RBE for the CHO-K1 cell line in a passively delivered clinical proton spread out Bragg peak (SOBP) is determined both in vitro and using a silicon-on-insulator (SOI) microdosimetry method paired with the modified microdosimetric kinetic model. The RBE along the central axis of a SOBP with 2 Gy delivered at the middle of the treatment field was found to vary between 1.11–1.98 and the RBE for 10% cell survival between 1.07–1.58 with a 250 kVp x-ray reference radiation and between 1.19–2.34 and 0.95–1.41, respectively, for a Co60 reference. Good agreement was found between RBE values calculated from the SOI-microdosimetry-MKM approach and in vitro. A strong correlation between proton lineal energy and RBE was observed particularly in the distal end and falloff of the SOBP.

KW - proton therapy

KW - RBE

KW - microdosimetry

KW - MKM

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/31290325

U2 - 10.1088/1361-6560/aaec2f/meta

DO - 10.1088/1361-6560/aaec2f/meta

M3 - Article

VL - 63

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

M1 - 235007

ER -

ID: 4617474