Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease
occurring in approximately 1% of the worldwide population.
The disease primarily affects the joints, where inflammatory
cells, such as macrophages, invade the synovium and cause
cartilage and bone destruction. Currently, it is difficult to
efficiently diagnose and monitor early-stage RA. In this study,
we investigated whether SPECT/micro-CT imaging with 99mTclabeled
Nanobodies directed against the macrophage mannose
receptor (MMR) is a useful tool for monitoring and quantifying
joint inflammation in collagen-induced arthritis (CIA), a mouse
model for RA. The expression of MMR was analyzed on macrophages
and osteoclasts generated in vitro and in cells obtained
from various organs from mice with CIA.
Details
Original language | English |
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Pages (from-to) | 807-814 |
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Journal | Journal of Nuclear Medicine |
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Volume | 54 |
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Issue number | 5 |
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DOIs | |
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Publication status | Published - 27 Feb 2013 |
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