SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis

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Authors

  • Stéphanie Put
  • Steve Schoonooghe
  • Nick Devoogdt
  • Evelien Schurgers
  • Anneleen Avau
  • Tania Mitera
  • Matthias D'huyvetter
  • Patrick De Baetselier
  • Geert Raes
  • Tony Lahoutte
  • Patrick Matthys

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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease occurring in approximately 1% of the worldwide population. The disease primarily affects the joints, where inflammatory cells, such as macrophages, invade the synovium and cause cartilage and bone destruction. Currently, it is difficult to efficiently diagnose and monitor early-stage RA. In this study, we investigated whether SPECT/micro-CT imaging with 99mTclabeled Nanobodies directed against the macrophage mannose receptor (MMR) is a useful tool for monitoring and quantifying joint inflammation in collagen-induced arthritis (CIA), a mouse model for RA. The expression of MMR was analyzed on macrophages and osteoclasts generated in vitro and in cells obtained from various organs from mice with CIA.

Details

Original languageEnglish
Pages (from-to)807-814
JournalJournal of Nuclear Medicine
Volume54
Issue number5
DOIs
StatePublished - 27 Feb 2013

Keywords

  • Rheumatoid Arthritis, Nanobody, Mannose Receptor, SPECT imaging

ID: 314889