SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis

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SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis. / Put, Stéphanie; Schoonooghe, Steve; Devoogdt, Nick; Schurgers, Evelien; Avau, Anneleen; Mitera, Tania; D'huyvetter, Matthias; De Baetselier, Patrick; Raes, Geert; Lahoutte, Tony; Matthys, Patrick; Baatout, Sarah (Peer reviewer); Aerts, An (Peer reviewer); Impens, Nathalie (Peer reviewer).

In: Journal of Nuclear Medicine, Vol. 54, No. 5, 27.02.2013, p. 807-814.

Research output: Contribution to journalArticle

Harvard

Put, S, Schoonooghe, S, Devoogdt, N, Schurgers, E, Avau, A, Mitera, T, D'huyvetter, M, De Baetselier, P, Raes, G, Lahoutte, T, Matthys, P, Baatout, S, Aerts, A & Impens, N 2013, 'SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis', Journal of Nuclear Medicine, vol. 54, no. 5, pp. 807-814. https://doi.org/10.2967/jnumed.112.111781

APA

Put, S., Schoonooghe, S., Devoogdt, N., Schurgers, E., Avau, A., Mitera, T., ... Impens, N. (2013). SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis. Journal of Nuclear Medicine, 54(5), 807-814. https://doi.org/10.2967/jnumed.112.111781

Vancouver

Put S, Schoonooghe S, Devoogdt N, Schurgers E, Avau A, Mitera T et al. SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis. Journal of Nuclear Medicine. 2013 Feb 27;54(5):807-814. https://doi.org/10.2967/jnumed.112.111781

Author

Put, Stéphanie ; Schoonooghe, Steve ; Devoogdt, Nick ; Schurgers, Evelien ; Avau, Anneleen ; Mitera, Tania ; D'huyvetter, Matthias ; De Baetselier, Patrick ; Raes, Geert ; Lahoutte, Tony ; Matthys, Patrick ; Baatout, Sarah ; Aerts, An ; Impens, Nathalie. / SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis. In: Journal of Nuclear Medicine. 2013 ; Vol. 54, No. 5. pp. 807-814.

Bibtex - Download

@article{b347c93bc1cb469f9e33712bcb7bf61e,
title = "SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis",
abstract = "Rheumatoid arthritis (RA) is a chronic autoimmune disease occurring in approximately 1{\%} of the worldwide population. The disease primarily affects the joints, where inflammatory cells, such as macrophages, invade the synovium and cause cartilage and bone destruction. Currently, it is difficult to efficiently diagnose and monitor early-stage RA. In this study, we investigated whether SPECT/micro-CT imaging with 99mTclabeled Nanobodies directed against the macrophage mannose receptor (MMR) is a useful tool for monitoring and quantifying joint inflammation in collagen-induced arthritis (CIA), a mouse model for RA. The expression of MMR was analyzed on macrophages and osteoclasts generated in vitro and in cells obtained from various organs from mice with CIA.",
keywords = "Rheumatoid Arthritis, Nanobody, Mannose Receptor, SPECT imaging",
author = "St{\'e}phanie Put and Steve Schoonooghe and Nick Devoogdt and Evelien Schurgers and Anneleen Avau and Tania Mitera and Matthias D'huyvetter and {De Baetselier}, Patrick and Geert Raes and Tony Lahoutte and Patrick Matthys and Sarah Baatout and An Aerts and Nathalie Impens",
note = "Score = 10",
year = "2013",
month = "2",
day = "27",
doi = "10.2967/jnumed.112.111781",
language = "English",
volume = "54",
pages = "807--814",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "SNMMI - Society of Nuclear Medicine and Molecular Imaging",
number = "5",

}

RIS - Download

TY - JOUR

T1 - SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis

AU - Put, Stéphanie

AU - Schoonooghe, Steve

AU - Devoogdt, Nick

AU - Schurgers, Evelien

AU - Avau, Anneleen

AU - Mitera, Tania

AU - D'huyvetter, Matthias

AU - De Baetselier, Patrick

AU - Raes, Geert

AU - Lahoutte, Tony

AU - Matthys, Patrick

A2 - Baatout, Sarah

A2 - Aerts, An

A2 - Impens, Nathalie

N1 - Score = 10

PY - 2013/2/27

Y1 - 2013/2/27

N2 - Rheumatoid arthritis (RA) is a chronic autoimmune disease occurring in approximately 1% of the worldwide population. The disease primarily affects the joints, where inflammatory cells, such as macrophages, invade the synovium and cause cartilage and bone destruction. Currently, it is difficult to efficiently diagnose and monitor early-stage RA. In this study, we investigated whether SPECT/micro-CT imaging with 99mTclabeled Nanobodies directed against the macrophage mannose receptor (MMR) is a useful tool for monitoring and quantifying joint inflammation in collagen-induced arthritis (CIA), a mouse model for RA. The expression of MMR was analyzed on macrophages and osteoclasts generated in vitro and in cells obtained from various organs from mice with CIA.

AB - Rheumatoid arthritis (RA) is a chronic autoimmune disease occurring in approximately 1% of the worldwide population. The disease primarily affects the joints, where inflammatory cells, such as macrophages, invade the synovium and cause cartilage and bone destruction. Currently, it is difficult to efficiently diagnose and monitor early-stage RA. In this study, we investigated whether SPECT/micro-CT imaging with 99mTclabeled Nanobodies directed against the macrophage mannose receptor (MMR) is a useful tool for monitoring and quantifying joint inflammation in collagen-induced arthritis (CIA), a mouse model for RA. The expression of MMR was analyzed on macrophages and osteoclasts generated in vitro and in cells obtained from various organs from mice with CIA.

KW - Rheumatoid Arthritis

KW - Nanobody

KW - Mannose Receptor

KW - SPECT imaging

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_128828

UR - http://knowledgecentre.sckcen.be/so2/bibref/10211

U2 - 10.2967/jnumed.112.111781

DO - 10.2967/jnumed.112.111781

M3 - Article

VL - 54

SP - 807

EP - 814

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 5

ER -

ID: 314889