Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-Exposed Arabidopsis thaliana

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Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-Exposed Arabidopsis thaliana. / Hendrix, Sophie; Iven, Verena; Eekhout, Thomas; Huybrechts, Michiel; Pecqueur, Ingeborg; Horemans, Nele; Keunen, Els; De Veylder, Lieven; Vangronsveld, Jaco; Cuypers, Ann.

In: Frontiers in Plant Science, Vol. 11, 366, 03.04.2020, p. 1-13.

Research output: Contribution to journalArticlepeer-review

Harvard

Hendrix, S, Iven, V, Eekhout, T, Huybrechts, M, Pecqueur, I, Horemans, N, Keunen, E, De Veylder, L, Vangronsveld, J & Cuypers, A 2020, 'Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-Exposed Arabidopsis thaliana', Frontiers in Plant Science, vol. 11, 366, pp. 1-13. https://doi.org/10.3389/fpls.2020.00366

APA

Hendrix, S., Iven, V., Eekhout, T., Huybrechts, M., Pecqueur, I., Horemans, N., Keunen, E., De Veylder, L., Vangronsveld, J., & Cuypers, A. (2020). Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-Exposed Arabidopsis thaliana. Frontiers in Plant Science, 11, 1-13. [366]. https://doi.org/10.3389/fpls.2020.00366

Author

Hendrix, Sophie ; Iven, Verena ; Eekhout, Thomas ; Huybrechts, Michiel ; Pecqueur, Ingeborg ; Horemans, Nele ; Keunen, Els ; De Veylder, Lieven ; Vangronsveld, Jaco ; Cuypers, Ann. / Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-Exposed Arabidopsis thaliana. In: Frontiers in Plant Science. 2020 ; Vol. 11. pp. 1-13.

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@article{e1a576a5b9d34334b6adb3925bad3940,
title = "Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-Exposed Arabidopsis thaliana",
abstract = "Cadmium (Cd) exposure causes an oxidative challenge and inhibits cell cycle progression, ultimately impacting plant growth. Stress-induced effects on the cell cycle are often a consequence of activation of the DNA damage response (DDR). The main aim of this study was to investigate the role of the transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) and three downstream cyclin-dependent kinase inhibitors of the SIAMESE-RELATED (SMR) family in the Cd-induced DDR and oxidative challenge in leaves of Arabidopsis thaliana. Effects of Cd on plant growth, cell cycle regulation and the expression of DDR genes were highly similar between the wildtype and smr4/5/7 mutant. In contrast, sog1-7 mutant leaves displayed a much lower Cd sensitivity within the experimental time-frame and significantly less pronounced upregulations of DDR-related genes, indicating the involvement of SOG1 in the Cdinduced DDR. Cadmium-induced responses related to the oxidative challenge were disturbed in the sog1-7 mutant, as indicated by delayed Cd-induced increases of hydrogen peroxide and glutathione concentrations and lower upregulations of oxidative stress-related genes. In conclusion, our results attribute a novel role to SOG1 in regulating the oxidative stress response and connect oxidative stress to the DDR in Cd-exposed plants.",
keywords = "Arabidopsis thaliana, Cadmium, DNA damage response, oxidative stress response, SIAMESE-related, Suppressor of gamma response 1",
author = "Sophie Hendrix and Verena Iven and Thomas Eekhout and Michiel Huybrechts and Ingeborg Pecqueur and Nele Horemans and Els Keunen and {De Veylder}, Lieven and Jaco Vangronsveld and Ann Cuypers",
note = "Score=10",
year = "2020",
month = apr,
day = "3",
doi = "10.3389/fpls.2020.00366",
language = "English",
volume = "11",
pages = "1--13",
journal = "Frontiers in Plant Science",
issn = "1664-462X",
publisher = "Frontiers Media",

}

RIS - Download

TY - JOUR

T1 - Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-Exposed Arabidopsis thaliana

AU - Hendrix, Sophie

AU - Iven, Verena

AU - Eekhout, Thomas

AU - Huybrechts, Michiel

AU - Pecqueur, Ingeborg

AU - Horemans, Nele

AU - Keunen, Els

AU - De Veylder, Lieven

AU - Vangronsveld, Jaco

AU - Cuypers, Ann

N1 - Score=10

PY - 2020/4/3

Y1 - 2020/4/3

N2 - Cadmium (Cd) exposure causes an oxidative challenge and inhibits cell cycle progression, ultimately impacting plant growth. Stress-induced effects on the cell cycle are often a consequence of activation of the DNA damage response (DDR). The main aim of this study was to investigate the role of the transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) and three downstream cyclin-dependent kinase inhibitors of the SIAMESE-RELATED (SMR) family in the Cd-induced DDR and oxidative challenge in leaves of Arabidopsis thaliana. Effects of Cd on plant growth, cell cycle regulation and the expression of DDR genes were highly similar between the wildtype and smr4/5/7 mutant. In contrast, sog1-7 mutant leaves displayed a much lower Cd sensitivity within the experimental time-frame and significantly less pronounced upregulations of DDR-related genes, indicating the involvement of SOG1 in the Cdinduced DDR. Cadmium-induced responses related to the oxidative challenge were disturbed in the sog1-7 mutant, as indicated by delayed Cd-induced increases of hydrogen peroxide and glutathione concentrations and lower upregulations of oxidative stress-related genes. In conclusion, our results attribute a novel role to SOG1 in regulating the oxidative stress response and connect oxidative stress to the DDR in Cd-exposed plants.

AB - Cadmium (Cd) exposure causes an oxidative challenge and inhibits cell cycle progression, ultimately impacting plant growth. Stress-induced effects on the cell cycle are often a consequence of activation of the DNA damage response (DDR). The main aim of this study was to investigate the role of the transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) and three downstream cyclin-dependent kinase inhibitors of the SIAMESE-RELATED (SMR) family in the Cd-induced DDR and oxidative challenge in leaves of Arabidopsis thaliana. Effects of Cd on plant growth, cell cycle regulation and the expression of DDR genes were highly similar between the wildtype and smr4/5/7 mutant. In contrast, sog1-7 mutant leaves displayed a much lower Cd sensitivity within the experimental time-frame and significantly less pronounced upregulations of DDR-related genes, indicating the involvement of SOG1 in the Cdinduced DDR. Cadmium-induced responses related to the oxidative challenge were disturbed in the sog1-7 mutant, as indicated by delayed Cd-induced increases of hydrogen peroxide and glutathione concentrations and lower upregulations of oxidative stress-related genes. In conclusion, our results attribute a novel role to SOG1 in regulating the oxidative stress response and connect oxidative stress to the DDR in Cd-exposed plants.

KW - Arabidopsis thaliana

KW - Cadmium

KW - DNA damage response

KW - oxidative stress response

KW - SIAMESE-related

KW - Suppressor of gamma response 1

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/38096023

U2 - 10.3389/fpls.2020.00366

DO - 10.3389/fpls.2020.00366

M3 - Article

VL - 11

SP - 1

EP - 13

JO - Frontiers in Plant Science

JF - Frontiers in Plant Science

SN - 1664-462X

M1 - 366

ER -

ID: 6773145