TERF1 and TERF2 downregulate telomere length in cognitive deficit at the late period after low-dose exposure.

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Abstract

Purpose - to explore the role of radiation dose on gene regulation of telomere length and its influence on the patho-genesis of cerebrovascular neurocognitive deficit at the remote period of low-dose irradiation as a result of the Chornobyl accident. Materials and methods. We performed a study of TERF1, TERF2 and TERT genes expression (GE) by RT-PCR, and relative telomere length (RTL) by flow-FISH in 258 clean-up workers of Chornobyl accident divided by radiation dose groups (range 22-2800 mSv) and 78 controls with vascular cognitive deficit.

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Original languageEnglish
Pages (from-to)170-185
JournalProblems of radiation medicine and radiobiology
Volume19
Issue number09
Publication statusPublished - Sep 2014

Keywords

  • Chornobyl, TERF1, TERF2, TERT, cognitive deficit, gene expression, low-dose radiation, telomeres

ID: 190523