The current knowledge on radiosensitivity of ovarian follicle development stages

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The current knowledge on radiosensitivity of ovarian follicle development stages. / Adriaens, Iris; Smitz, Johan; Jacquet, Paul; Baatout, Sarah (Peer reviewer).

In: Human Reproduction Update, Vol. 15, No. 3, 05.2009, p. 359-377.

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Adriaens, Iris ; Smitz, Johan ; Jacquet, Paul ; Baatout, Sarah. / The current knowledge on radiosensitivity of ovarian follicle development stages. In: Human Reproduction Update. 2009 ; Vol. 15, No. 3. pp. 359-377.

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@article{bcd33b6586bf45728c277d05ea626c44,
title = "The current knowledge on radiosensitivity of ovarian follicle development stages",
abstract = "Quantitative human data on the risks of genetically transmissible diseases and anomalies following exposure to ionizing radiation are scarce. As such, the most comprehensive data on these effects have come from experiments with laboratory animals. However, oocyte radiosensitivity as well as the pattern of oocyte radiosensitivity from the immature resting stage to the fully grown pre-ovulatory stage, differs tremendously between species. These features make it hard to extrapolate follicle radiosensitivity results found in different species to the human female population. Additionally, data describing radiosensitivity patterns is mostly coming from in-vivo studies that are not easy to interpret, since all phases of folliculogenesis are present at the same time in the ovaries. Results discussed in papers mostly describe the radiosensitivity at single or discrete moments during the cycle or around the moment of ovulation and is not always {"}translated{"} to the radiosensitivity of a well defined follicular class. The objective of this paper is to review the in-vivo studies that reported on the radiosensitivity of female germ cells and to “translate” the existing information in terms of follicle sensitivity at the different stages of development.",
keywords = "oocytes, fertility, genetic effects, ionising radiation, radiosensitivity",
author = "Iris Adriaens and Johan Smitz and Paul Jacquet and Sarah Baatout",
note = "Score = 10",
year = "2009",
month = "5",
doi = "10.1093/humupd/dmn063",
language = "English",
volume = "15",
pages = "359--377",
journal = "Human Reproduction Update",
issn = "1355-4786",
publisher = "Oxford University Press",
number = "3",

}

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TY - JOUR

T1 - The current knowledge on radiosensitivity of ovarian follicle development stages

AU - Adriaens, Iris

AU - Smitz, Johan

AU - Jacquet, Paul

A2 - Baatout, Sarah

N1 - Score = 10

PY - 2009/5

Y1 - 2009/5

N2 - Quantitative human data on the risks of genetically transmissible diseases and anomalies following exposure to ionizing radiation are scarce. As such, the most comprehensive data on these effects have come from experiments with laboratory animals. However, oocyte radiosensitivity as well as the pattern of oocyte radiosensitivity from the immature resting stage to the fully grown pre-ovulatory stage, differs tremendously between species. These features make it hard to extrapolate follicle radiosensitivity results found in different species to the human female population. Additionally, data describing radiosensitivity patterns is mostly coming from in-vivo studies that are not easy to interpret, since all phases of folliculogenesis are present at the same time in the ovaries. Results discussed in papers mostly describe the radiosensitivity at single or discrete moments during the cycle or around the moment of ovulation and is not always "translated" to the radiosensitivity of a well defined follicular class. The objective of this paper is to review the in-vivo studies that reported on the radiosensitivity of female germ cells and to “translate” the existing information in terms of follicle sensitivity at the different stages of development.

AB - Quantitative human data on the risks of genetically transmissible diseases and anomalies following exposure to ionizing radiation are scarce. As such, the most comprehensive data on these effects have come from experiments with laboratory animals. However, oocyte radiosensitivity as well as the pattern of oocyte radiosensitivity from the immature resting stage to the fully grown pre-ovulatory stage, differs tremendously between species. These features make it hard to extrapolate follicle radiosensitivity results found in different species to the human female population. Additionally, data describing radiosensitivity patterns is mostly coming from in-vivo studies that are not easy to interpret, since all phases of folliculogenesis are present at the same time in the ovaries. Results discussed in papers mostly describe the radiosensitivity at single or discrete moments during the cycle or around the moment of ovulation and is not always "translated" to the radiosensitivity of a well defined follicular class. The objective of this paper is to review the in-vivo studies that reported on the radiosensitivity of female germ cells and to “translate” the existing information in terms of follicle sensitivity at the different stages of development.

KW - oocytes

KW - fertility

KW - genetic effects

KW - ionising radiation

KW - radiosensitivity

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_97770

UR - http://knowledgecentre.sckcen.be/so2/bibref/5838

U2 - 10.1093/humupd/dmn063

DO - 10.1093/humupd/dmn063

M3 - Article

VL - 15

SP - 359

EP - 377

JO - Human Reproduction Update

JF - Human Reproduction Update

SN - 1355-4786

IS - 3

ER -

ID: 128915