The ESA IBER-3 project - Gene expression and cytokine monitoring for biodosimetry and radiation sensitivity screening (GYMBRASS)

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The ESA IBER-3 project - Gene expression and cytokine monitoring for biodosimetry and radiation sensitivity screening (GYMBRASS). / Quintens, Roel; Moreels, Marjan; Tabury, Kevin; Macaeva, Ellina; Michaux, Arlette; Averbeck, Nicole; Choukèr, Alexander; Baatout, Sarah.

SP-706 Life in Space for Life on Earth. Noordwijk, Netherlands, 2013. (Spacebooks Online; No. SP-706).

Research output: Contribution to report/book/conference proceedingsIn-proceedings paper

Harvard

Quintens, R, Moreels, M, Tabury, K, Macaeva, E, Michaux, A, Averbeck, N, Choukèr, A & Baatout, S 2013, The ESA IBER-3 project - Gene expression and cytokine monitoring for biodosimetry and radiation sensitivity screening (GYMBRASS). in SP-706 Life in Space for Life on Earth. Spacebooks Online, no. SP-706, Noordwijk, Netherlands, Life in Space for Life on Earth, Aberdeen, United Kingdom, 2012-06-17.

Vancouver

Quintens R, Moreels M, Tabury K, Macaeva E, Michaux A, Averbeck N et al. The ESA IBER-3 project - Gene expression and cytokine monitoring for biodosimetry and radiation sensitivity screening (GYMBRASS). In SP-706 Life in Space for Life on Earth. Noordwijk, Netherlands. 2013. (Spacebooks Online; SP-706).

Bibtex - Download

@inproceedings{e44efbc9df254a55a7db253e6a38cb62,
title = "The ESA IBER-3 project - Gene expression and cytokine monitoring for biodosimetry and radiation sensitivity screening (GYMBRASS)",
abstract = "In order to better understand and define the biological risks of cosmic radiation, it is important to identify biomarkers for exposure and for predicting individual sensitivity to radiation-induced biological damage. Our study aims at identifying new biomarkers for radiation exposure to low and high linear energy transfer (LET) radiation. We will focus on the use of gene, exon and/or cytokine expression signatures in human peripheral blood mononuclear cells (PBMCs) as biomarkers. These data will be integrated with those from DNA double strand break (DSB) repair kinetics in order to identify biomarkers of individual radiosensitivity. Our preliminary data indicate that gene/exon expression signatures can be used to accurately predict radiation doses of below 0.1 Gy (X-rays). Additionally, specific exon signatures may further enhance the sensitivity of prediction. Also, we found that there is a very strong overlap between gene expression changes in response to high doses (1 Gy) of low (X-ray) and high-LET (C-ions; 50-75 keV/μm) irradiation. However, we also identified genes that only responded to either X-rays or C-ions, suggesting that LET-specific gene signatures may also be identified.",
keywords = "Biodosimetry, gene expression, alternative splicing, DNA damage",
author = "Roel Quintens and Marjan Moreels and Kevin Tabury and Ellina Macaeva and Arlette Michaux and Nicole Averbeck and Alexander Chouk{\`e}r and Sarah Baatout",
note = "Score = 3",
year = "2013",
month = "4",
language = "English",
isbn = "978-92-9221-270-4",
series = "Spacebooks Online",
number = "SP-706",
booktitle = "SP-706 Life in Space for Life on Earth",

}

RIS - Download

TY - GEN

T1 - The ESA IBER-3 project - Gene expression and cytokine monitoring for biodosimetry and radiation sensitivity screening (GYMBRASS)

AU - Quintens, Roel

AU - Moreels, Marjan

AU - Tabury, Kevin

AU - Macaeva, Ellina

AU - Michaux, Arlette

AU - Averbeck, Nicole

AU - Choukèr, Alexander

AU - Baatout, Sarah

N1 - Score = 3

PY - 2013/4

Y1 - 2013/4

N2 - In order to better understand and define the biological risks of cosmic radiation, it is important to identify biomarkers for exposure and for predicting individual sensitivity to radiation-induced biological damage. Our study aims at identifying new biomarkers for radiation exposure to low and high linear energy transfer (LET) radiation. We will focus on the use of gene, exon and/or cytokine expression signatures in human peripheral blood mononuclear cells (PBMCs) as biomarkers. These data will be integrated with those from DNA double strand break (DSB) repair kinetics in order to identify biomarkers of individual radiosensitivity. Our preliminary data indicate that gene/exon expression signatures can be used to accurately predict radiation doses of below 0.1 Gy (X-rays). Additionally, specific exon signatures may further enhance the sensitivity of prediction. Also, we found that there is a very strong overlap between gene expression changes in response to high doses (1 Gy) of low (X-ray) and high-LET (C-ions; 50-75 keV/μm) irradiation. However, we also identified genes that only responded to either X-rays or C-ions, suggesting that LET-specific gene signatures may also be identified.

AB - In order to better understand and define the biological risks of cosmic radiation, it is important to identify biomarkers for exposure and for predicting individual sensitivity to radiation-induced biological damage. Our study aims at identifying new biomarkers for radiation exposure to low and high linear energy transfer (LET) radiation. We will focus on the use of gene, exon and/or cytokine expression signatures in human peripheral blood mononuclear cells (PBMCs) as biomarkers. These data will be integrated with those from DNA double strand break (DSB) repair kinetics in order to identify biomarkers of individual radiosensitivity. Our preliminary data indicate that gene/exon expression signatures can be used to accurately predict radiation doses of below 0.1 Gy (X-rays). Additionally, specific exon signatures may further enhance the sensitivity of prediction. Also, we found that there is a very strong overlap between gene expression changes in response to high doses (1 Gy) of low (X-ray) and high-LET (C-ions; 50-75 keV/μm) irradiation. However, we also identified genes that only responded to either X-rays or C-ions, suggesting that LET-specific gene signatures may also be identified.

KW - Biodosimetry

KW - gene expression

KW - alternative splicing

KW - DNA damage

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_128154

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_128154_2

UR - http://knowledgecentre.sckcen.be/so2/bibref/10127

M3 - In-proceedings paper

SN - 978-92-9221-270-4

T3 - Spacebooks Online

BT - SP-706 Life in Space for Life on Earth

CY - Noordwijk, Netherlands

ER -

ID: 298002