The role of connexin proteins and their channels in radiation‑induced atherosclerosis

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The role of connexin proteins and their channels in radiation‑induced atherosclerosis. / Ramadan, Raghda; Baatout, Sarah; Aerts, An; Leybaert, Luc.

In: Cellular and Molecular Life Science, 03.01.2021, p. 1-16.

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@article{11e74fc4caf84a018d441b7b64468edd,
title = "The role of connexin proteins and their channels in radiation‑induced atherosclerosis",
abstract = "Radiotherapy is an effective treatment for breast cancer and other thoracic tumors. However, while high-energy radiotherapy treatment successfully kills cancer cells, radiation exposure of the heart and large arteries cannot always be avoided, resulting in secondary cardiovascular disease in cancer survivors. Radiation-induced changes in the cardiac vasculature may thereby lead to coronary artery atherosclerosis, which is a major cardiovascular complication nowadays in thoracic radiotherapytreated patients. The underlying biological and molecular mechanisms of radiation-induced atherosclerosis are complex and still not fully understood, resulting in potentially improper radiation protection. Ionizing radiation (IR) exposure may damage the vascular endothelium by inducing DNA damage, oxidative stress, premature cellular senescence, cell death and inflammation, which act to promote the atherosclerotic process. Intercellular communication mediated by connexin (Cx)-based gap junctions and hemichannels may modulate IR-induced responses and thereby the atherosclerotic process. However, the role of endothelial Cxs and their channels in atherosclerotic development after IR exposure is still poorly defined. A better understanding of the underlying biological pathways involved in secondary cardiovascular toxicity after radiotherapy would facilitate the development of effective strategies that prevent or mitigate these adverse effects. Here,",
keywords = "Review article CMLS, Connexin, Intercellular communication, Ionizing radiation, Atherosclerosis, Bystander effect, Gap junction, Hemichannels",
author = "Raghda Ramadan and Sarah Baatout and An Aerts and Luc Leybaert",
note = "Score=10",
year = "2021",
month = "1",
day = "3",
doi = "10.1007/s00018-020-03716-3",
language = "English",
pages = "1--16",
journal = "Cellular and Molecular Life Science",
issn = "1420-682X",
publisher = "Springer",

}

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TY - JOUR

T1 - The role of connexin proteins and their channels in radiation‑induced atherosclerosis

AU - Ramadan, Raghda

AU - Baatout, Sarah

AU - Aerts, An

AU - Leybaert, Luc

N1 - Score=10

PY - 2021/1/3

Y1 - 2021/1/3

N2 - Radiotherapy is an effective treatment for breast cancer and other thoracic tumors. However, while high-energy radiotherapy treatment successfully kills cancer cells, radiation exposure of the heart and large arteries cannot always be avoided, resulting in secondary cardiovascular disease in cancer survivors. Radiation-induced changes in the cardiac vasculature may thereby lead to coronary artery atherosclerosis, which is a major cardiovascular complication nowadays in thoracic radiotherapytreated patients. The underlying biological and molecular mechanisms of radiation-induced atherosclerosis are complex and still not fully understood, resulting in potentially improper radiation protection. Ionizing radiation (IR) exposure may damage the vascular endothelium by inducing DNA damage, oxidative stress, premature cellular senescence, cell death and inflammation, which act to promote the atherosclerotic process. Intercellular communication mediated by connexin (Cx)-based gap junctions and hemichannels may modulate IR-induced responses and thereby the atherosclerotic process. However, the role of endothelial Cxs and their channels in atherosclerotic development after IR exposure is still poorly defined. A better understanding of the underlying biological pathways involved in secondary cardiovascular toxicity after radiotherapy would facilitate the development of effective strategies that prevent or mitigate these adverse effects. Here,

AB - Radiotherapy is an effective treatment for breast cancer and other thoracic tumors. However, while high-energy radiotherapy treatment successfully kills cancer cells, radiation exposure of the heart and large arteries cannot always be avoided, resulting in secondary cardiovascular disease in cancer survivors. Radiation-induced changes in the cardiac vasculature may thereby lead to coronary artery atherosclerosis, which is a major cardiovascular complication nowadays in thoracic radiotherapytreated patients. The underlying biological and molecular mechanisms of radiation-induced atherosclerosis are complex and still not fully understood, resulting in potentially improper radiation protection. Ionizing radiation (IR) exposure may damage the vascular endothelium by inducing DNA damage, oxidative stress, premature cellular senescence, cell death and inflammation, which act to promote the atherosclerotic process. Intercellular communication mediated by connexin (Cx)-based gap junctions and hemichannels may modulate IR-induced responses and thereby the atherosclerotic process. However, the role of endothelial Cxs and their channels in atherosclerotic development after IR exposure is still poorly defined. A better understanding of the underlying biological pathways involved in secondary cardiovascular toxicity after radiotherapy would facilitate the development of effective strategies that prevent or mitigate these adverse effects. Here,

KW - Review article CMLS

KW - Connexin

KW - Intercellular communication

KW - Ionizing radiation

KW - Atherosclerosis

KW - Bystander effect

KW - Gap junction

KW - Hemichannels

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/42035777

U2 - 10.1007/s00018-020-03716-3

DO - 10.1007/s00018-020-03716-3

M3 - Article

SP - 1

EP - 16

JO - Cellular and Molecular Life Science

JF - Cellular and Molecular Life Science

SN - 1420-682X

ER -

ID: 7016466