Therapeutic proton beams: LET, RBE and microdosimetric spectra with gas and silicon detectors

Research output: Contribution to journalArticle

Authors

  • Paolo Colautti
  • Anna Bianchi
  • Anna Selva
  • Davide Bortot
  • Davide Mazzucconi
  • Andrea Pola
  • Stefano Agosteo
  • Giada Petringa
  • Pablo G.A. Cirrone
  • Valeria Conte

Institutes & Expert groups

  • INFN - Instituto Nazionale di Fisica Nucleare
  • POLIMI - Politecnico di Milano
  • ELI-Beamlines

Documents & links

Abstract

A sealed mini-TEPC able to work in gas-steady modality, a monolithic silicon device composed by a matrix of micrometric cylindrical diodes and a residual energy measurement stage and the silicon MicroPlus Bridge detector were used to perform microdosimetric measurements at the 62 MeV proton clinical SOBP of CATANA at the Southern National Laboratories of INFN (LNS – INFN, Catania, Italy). Measurements were taken at the same different positions in a PMMA phantom, in order to analyse the detector response differences. Finally, a weighting function was applied to the spectra to see if the microdosimetric detectors are able to monitor RBE data for glioma cells (U87) irradiated at six positions along the same modulated 62-MeV proton beam. The results obtained with the three microdosimeters are compared and discussed.

Details

Original languageEnglish
Article number106386
Pages (from-to)1-5
Number of pages5
JournalRadiation Measurements
Volume136
DOIs
Publication statusPublished - 3 Jun 2020

Keywords

  • Microdosimetry, Proton therapy, Proton RBE, Mini-TEPC, Silicon telescope detector, MicroPlus Bridge detector

ID: 6919360