Ultrastructural and Immunocytochemical Analysis of Multilineage Differentiated Human Dental Pulp- and Umbilical Cord-Derived Mesenchymal Stem Cells

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Ultrastructural and Immunocytochemical Analysis of Multilineage Differentiated Human Dental Pulp- and Umbilical Cord-Derived Mesenchymal Stem Cells. / Struys, Tom; Moreels, Marjan; Martens, Wendy; Donders, Raf; Wolfs, Esther; Lambrichts, Ivo; Baatout, Sarah (Peer reviewer).

In: Cells Tissues Organs, Vol. 193, No. 6, 05.2011, p. 366-378.

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Struys, Tom ; Moreels, Marjan ; Martens, Wendy ; Donders, Raf ; Wolfs, Esther ; Lambrichts, Ivo ; Baatout, Sarah. / Ultrastructural and Immunocytochemical Analysis of Multilineage Differentiated Human Dental Pulp- and Umbilical Cord-Derived Mesenchymal Stem Cells. In: Cells Tissues Organs. 2011 ; Vol. 193, No. 6. pp. 366-378.

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@article{8deeb1a0e54e47c99299a082abfb9817,
title = "Ultrastructural and Immunocytochemical Analysis of Multilineage Differentiated Human Dental Pulp- and Umbilical Cord-Derived Mesenchymal Stem Cells",
abstract = "Mesenchymal stem cells (MSCs) are one of the most promising stem cell types due to their availability and relatively simple requirements for in vitro expansion and genetic manipulation. Besides the well-characterized MSCs derived from bone marrow, there is growing evidence suggesting that dental pulp and the umbilical cord matrix both contain a substantial amount of cells having properties similar to those of MSCs. In order to assess the potential of dental pulp-derived MSCs (DPSC) and umbilical cord-derived MSCs (UCSC) in future clinical applications, it is essential to gain more insight into their differentiation capacity and to evaluate the tissues formed by these cells. In the present study, the morphological and ultrastructural characteristics of DPSC and UCSC induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated.",
keywords = "Stem cells, Mesenchyme, Differentiation, Dental pulp, Umbilical cord, Ultrastructure, Adipogenesis, osteogenesis, chrondrogenesis",
author = "Tom Struys and Marjan Moreels and Wendy Martens and Raf Donders and Esther Wolfs and Ivo Lambrichts and Sarah Baatout",
note = "Score = 0",
year = "2011",
month = "5",
doi = "10.1159/000321400",
language = "English",
volume = "193",
pages = "366--378",
journal = "Cells Tissues Organs",
issn = "1422-6421",
publisher = "Karger",
number = "6",

}

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TY - JOUR

T1 - Ultrastructural and Immunocytochemical Analysis of Multilineage Differentiated Human Dental Pulp- and Umbilical Cord-Derived Mesenchymal Stem Cells

AU - Struys, Tom

AU - Moreels, Marjan

AU - Martens, Wendy

AU - Donders, Raf

AU - Wolfs, Esther

AU - Lambrichts, Ivo

A2 - Baatout, Sarah

N1 - Score = 0

PY - 2011/5

Y1 - 2011/5

N2 - Mesenchymal stem cells (MSCs) are one of the most promising stem cell types due to their availability and relatively simple requirements for in vitro expansion and genetic manipulation. Besides the well-characterized MSCs derived from bone marrow, there is growing evidence suggesting that dental pulp and the umbilical cord matrix both contain a substantial amount of cells having properties similar to those of MSCs. In order to assess the potential of dental pulp-derived MSCs (DPSC) and umbilical cord-derived MSCs (UCSC) in future clinical applications, it is essential to gain more insight into their differentiation capacity and to evaluate the tissues formed by these cells. In the present study, the morphological and ultrastructural characteristics of DPSC and UCSC induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated.

AB - Mesenchymal stem cells (MSCs) are one of the most promising stem cell types due to their availability and relatively simple requirements for in vitro expansion and genetic manipulation. Besides the well-characterized MSCs derived from bone marrow, there is growing evidence suggesting that dental pulp and the umbilical cord matrix both contain a substantial amount of cells having properties similar to those of MSCs. In order to assess the potential of dental pulp-derived MSCs (DPSC) and umbilical cord-derived MSCs (UCSC) in future clinical applications, it is essential to gain more insight into their differentiation capacity and to evaluate the tissues formed by these cells. In the present study, the morphological and ultrastructural characteristics of DPSC and UCSC induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated.

KW - Stem cells

KW - Mesenchyme

KW - Differentiation

KW - Dental pulp

KW - Umbilical cord

KW - Ultrastructure

KW - Adipogenesis

KW - osteogenesis

KW - chrondrogenesis

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_109370

UR - http://knowledgecentre.sckcen.be/so2/bibref/7385

U2 - 10.1159/000321400

DO - 10.1159/000321400

M3 - Article

VL - 193

SP - 366

EP - 378

JO - Cells Tissues Organs

JF - Cells Tissues Organs

SN - 1422-6421

IS - 6

ER -

ID: 322529