Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization

Research output: Contribution to journalLiterature review

Standard

Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization. / Baatout, Sarah (Peer reviewer); Cortese, Franco; Klokov, Dmitry; Osipov, Andreyan; Stefaniak, Jakub ; Moreels, Marjan; Moskalev, Alexey ; Schastnaya, Jane ; Cantor, Charles ; Aliper, Alexander ; Mamoshina, Polina ; Ushakov, Igor ; Sapetsky, Alex ; Vanhaelen, Quentin ; Alchinova, Irina ; Karganov, Mikhail; Kovalchuk, Olga; Wilkins, Ruth; Shtemberg, Andrey ; Izumchenko, Evgeny ; Pedro de Magalhães, João ; V. Artemov, Artem ; Costes, Sylvain ; Beheshti, Afshin ; Wen Mao, Xiao; Pecaut, Michael ; Kaminskiy, Dmitry ; Ozerov, Ivan ; Scheibye-Knudsen, Morten S; Zhavoronkov, Alex .

In: Oncotarget - Impact Journals, Vol. Advance Publications 2018, 06.03.2018.

Research output: Contribution to journalLiterature review

Harvard

Baatout, S, Cortese, F, Klokov, D, Osipov, A, Stefaniak, J, Moreels, M, Moskalev, A, Schastnaya, J, Cantor, C, Aliper, A, Mamoshina, P, Ushakov, I, Sapetsky, A, Vanhaelen, Q, Alchinova, I, Karganov, M, Kovalchuk, O, Wilkins, R, Shtemberg, A, Izumchenko, E, Pedro de Magalhães, J, V. Artemov, A, Costes, S, Beheshti, A, Wen Mao, X, Pecaut, M, Kaminskiy, D, Ozerov, I, Scheibye-Knudsen, MS & Zhavoronkov, A 2018, 'Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization', Oncotarget - Impact Journals, vol. Advance Publications 2018.

APA

Baatout, S., Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moreels, M., ... Zhavoronkov, A. (2018). Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization. Oncotarget - Impact Journals, Advance Publications 2018.

Vancouver

Baatout S, Cortese F, Klokov D, Osipov A, Stefaniak J, Moreels M et al. Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization. Oncotarget - Impact Journals. 2018 Mar 6;Advance Publications 2018.

Author

Baatout, Sarah ; Cortese, Franco ; Klokov, Dmitry ; Osipov, Andreyan ; Stefaniak, Jakub ; Moreels, Marjan ; Moskalev, Alexey ; Schastnaya, Jane ; Cantor, Charles ; Aliper, Alexander ; Mamoshina, Polina ; Ushakov, Igor ; Sapetsky, Alex ; Vanhaelen, Quentin ; Alchinova, Irina ; Karganov, Mikhail ; Kovalchuk, Olga ; Wilkins, Ruth ; Shtemberg, Andrey ; Izumchenko, Evgeny ; Pedro de Magalhães, João ; V. Artemov, Artem ; Costes, Sylvain ; Beheshti, Afshin ; Wen Mao, Xiao ; Pecaut, Michael ; Kaminskiy, Dmitry ; Ozerov, Ivan ; Scheibye-Knudsen, Morten S ; Zhavoronkov, Alex . / Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization. In: Oncotarget - Impact Journals. 2018 ; Vol. Advance Publications 2018.

Bibtex - Download

@article{4c180377cf8640ee970c8a2de44ed541,
title = "Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization",
abstract = "While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.",
keywords = "radioresistance, space exploration, longevity, DNA damage, mars mission",
author = "Sarah Baatout and Franco Cortese and Dmitry Klokov and Andreyan Osipov and Jakub Stefaniak and Marjan Moreels and Alexey Moskalev and Jane Schastnaya and Charles Cantor and Alexander Aliper and Polina Mamoshina and Igor Ushakov and Alex Sapetsky and Quentin Vanhaelen and Irina Alchinova and Mikhail Karganov and Olga Kovalchuk and Ruth Wilkins and Andrey Shtemberg and Evgeny Izumchenko and {Pedro de Magalh{\~a}es}, Jo{\~a}o and {V. Artemov}, Artem and Sylvain Costes and Afshin Beheshti and {Wen Mao}, Xiao and Michael Pecaut and Dmitry Kaminskiy and Ivan Ozerov and Scheibye-Knudsen, {Morten S} and Alex Zhavoronkov",
note = "Score=10",
year = "2018",
month = "3",
day = "6",
language = "English",
volume = "Advance Publications 2018",
journal = "Oncotarget - Impact Journals",
issn = "1949-2553",
publisher = "Impact Journals",

}

RIS - Download

TY - JOUR

T1 - Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization

AU - Cortese, Franco

AU - Klokov, Dmitry

AU - Osipov, Andreyan

AU - Stefaniak, Jakub

AU - Moreels, Marjan

AU - Moskalev, Alexey

AU - Schastnaya, Jane

AU - Cantor, Charles

AU - Aliper, Alexander

AU - Mamoshina, Polina

AU - Ushakov, Igor

AU - Sapetsky, Alex

AU - Vanhaelen, Quentin

AU - Alchinova, Irina

AU - Karganov, Mikhail

AU - Kovalchuk, Olga

AU - Wilkins, Ruth

AU - Shtemberg, Andrey

AU - Izumchenko, Evgeny

AU - Pedro de Magalhães, João

AU - V. Artemov, Artem

AU - Costes, Sylvain

AU - Beheshti, Afshin

AU - Wen Mao, Xiao

AU - Pecaut, Michael

AU - Kaminskiy, Dmitry

AU - Ozerov, Ivan

AU - Scheibye-Knudsen, Morten S

AU - Zhavoronkov, Alex

A2 - Baatout, Sarah

N1 - Score=10

PY - 2018/3/6

Y1 - 2018/3/6

N2 - While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

AB - While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

KW - radioresistance

KW - space exploration

KW - longevity

KW - DNA damage

KW - mars mission

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/29343743

M3 - Literature review

VL - Advance Publications 2018

JO - Oncotarget - Impact Journals

JF - Oncotarget - Impact Journals

SN - 1949-2553

ER -

ID: 4081037