Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization

TY - JOUR

T1 - Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization

AU - Cortese, Franco

AU - Klokov, Dmitry

AU - Osipov, Andreyan

AU - Stefaniak, Jakub

AU - Moreels, Marjan

AU - Moskalev, Alexey

AU - Schastnaya, Jane

AU - Cantor, Charles

AU - Aliper, Alexander

AU - Mamoshina, Polina

AU - Ushakov, Igor

AU - Sapetsky, Alex

AU - Vanhaelen, Quentin

AU - Alchinova, Irina

AU - Karganov, Mikhail

AU - Kovalchuk, Olga

AU - Wilkins, Ruth

AU - Shtemberg, Andrey

AU - Izumchenko, Evgeny

AU - Pedro de Magalhães, João

AU - V. Artemov, Artem

AU - Costes, Sylvain

AU - Beheshti, Afshin

AU - Wen Mao, Xiao

AU - Pecaut, Michael

AU - Kaminskiy, Dmitry

AU - Ozerov, Ivan

AU - Scheibye-Knudsen, Morten S

AU - Zhavoronkov, Alex

A2 - Baatout, Sarah

N1 - Score=10

PY - 2018/3/6

Y1 - 2018/3/6

N2 - While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

AB - While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

KW - radioresistance

KW - space exploration

KW - longevity

KW - DNA damage

KW - mars mission

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/29343743

M3 - Literature review

VL - Advance Publications 2018

JO - Oncotarget - Impact Journals

JF - Oncotarget - Impact Journals

SN - 1949-2553

ER -