Research output: Contribution to journal › Literature review › peer-review
Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization. / Baatout, Sarah (Peer reviewer); Cortese, Franco; Klokov, Dmitry; Osipov, Andreyan; Stefaniak, Jakub ; Moreels, Marjan; Moskalev, Alexey ; Schastnaya, Jane ; Cantor, Charles ; Aliper, Alexander ; Mamoshina, Polina ; Ushakov, Igor ; Sapetsky, Alex ; Vanhaelen, Quentin ; Alchinova, Irina ; Karganov, Mikhail; Kovalchuk, Olga; Wilkins, Ruth; Shtemberg, Andrey ; Izumchenko, Evgeny ; Pedro de Magalhães, João ; V. Artemov, Artem ; Costes, Sylvain ; Beheshti, Afshin ; Wen Mao, Xiao; Pecaut, Michael ; Kaminskiy, Dmitry ; Ozerov, Ivan ; Scheibye-Knudsen, Morten S; Zhavoronkov, Alex .
In: Oncotarget - Impact Journals, Vol. Advance Publications 2018, 06.03.2018.Research output: Contribution to journal › Literature review › peer-review
}
TY - JOUR
T1 - Vive la radioresistance! converging research in radiobiologyand biogerontology to enhance human radioresistance for deepspace exploration and colonization
AU - Cortese, Franco
AU - Klokov, Dmitry
AU - Osipov, Andreyan
AU - Stefaniak, Jakub
AU - Moreels, Marjan
AU - Moskalev, Alexey
AU - Schastnaya, Jane
AU - Cantor, Charles
AU - Aliper, Alexander
AU - Mamoshina, Polina
AU - Ushakov, Igor
AU - Sapetsky, Alex
AU - Vanhaelen, Quentin
AU - Alchinova, Irina
AU - Karganov, Mikhail
AU - Kovalchuk, Olga
AU - Wilkins, Ruth
AU - Shtemberg, Andrey
AU - Izumchenko, Evgeny
AU - Pedro de Magalhães, João
AU - V. Artemov, Artem
AU - Costes, Sylvain
AU - Beheshti, Afshin
AU - Wen Mao, Xiao
AU - Pecaut, Michael
AU - Kaminskiy, Dmitry
AU - Ozerov, Ivan
AU - Scheibye-Knudsen, Morten S
AU - Zhavoronkov, Alex
A2 - Baatout, Sarah
N1 - Score=10
PY - 2018/3/6
Y1 - 2018/3/6
N2 - While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.
AB - While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.
KW - radioresistance
KW - space exploration
KW - longevity
KW - DNA damage
KW - mars mission
UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/29343743
M3 - Literature review
VL - Advance Publications 2018
JO - Oncotarget - Impact Journals
JF - Oncotarget - Impact Journals
SN - 1949-2553
ER -
ID: 4081037