X-irradiation induces cell death in fetal fibroblasts

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X-irradiation induces cell death in fetal fibroblasts. / Beck, Michaël; Moreels, Marjan; Jacquet, Paul; Van Oostveldt, Patrick; De Vos, Winnok; Baatout, Sarah.

In: International Journal of Molecular Medicine, Vol. 30, No. 1, 10.04.2012, p. 114-118.

Research output: Contribution to journalArticle

Harvard

Beck, M, Moreels, M, Jacquet, P, Van Oostveldt, P, De Vos, W & Baatout, S 2012, 'X-irradiation induces cell death in fetal fibroblasts', International Journal of Molecular Medicine, vol. 30, no. 1, pp. 114-118. https://doi.org/10.3892/ijmm.2012.964

APA

Beck, M., Moreels, M., Jacquet, P., Van Oostveldt, P., De Vos, W., & Baatout, S. (2012). X-irradiation induces cell death in fetal fibroblasts. International Journal of Molecular Medicine, 30(1), 114-118. https://doi.org/10.3892/ijmm.2012.964

Vancouver

Beck M, Moreels M, Jacquet P, Van Oostveldt P, De Vos W, Baatout S. X-irradiation induces cell death in fetal fibroblasts. International Journal of Molecular Medicine. 2012 Apr 10;30(1):114-118. https://doi.org/10.3892/ijmm.2012.964

Author

Beck, Michaël ; Moreels, Marjan ; Jacquet, Paul ; Van Oostveldt, Patrick ; De Vos, Winnok ; Baatout, Sarah. / X-irradiation induces cell death in fetal fibroblasts. In: International Journal of Molecular Medicine. 2012 ; Vol. 30, No. 1. pp. 114-118.

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@article{612883d198494779b8f98655286245af,
title = "X-irradiation induces cell death in fetal fibroblasts",
abstract = "The impact of ionizing radiation on developing organisms has been widely studied for risk assessment purposes. Even though efforts have been made to decrease received doses to as low as reasonably achievable, the possibility of accidental exposure has to be considered as well. Mammalian gestation is usually divided into three periods. Radiation exposure during the ‘pre-implantation period’ may essentially result in embryonic mortality while exposure during the ‘organogenesis period’ may characteristically lead to malformations. In humans, the ‘fetal period’ is one of particular sensitivity to radiation induction of mental retardation, especially if the exposure occurs between weeks 8-15 of gestation. It is also admitted that prenatal irradiation may increase the risk of leukemia and childhood cancer, with an equal risk over the whole pregnancy. The aim of this study was to investigate the effects of moderate to high doses of X-irradiation on mouse skin fetal fibroblasts, one of the cell types subjected to the highest dose of radiation. Exposure of the cells to X-rays led to a rapid and significant increase in γ-H2AX foci, indicative of high levels of DNA double strand breaks.",
keywords = "radiation, fibroblasts, fetal, apoptosis, DNA damage",
author = "Micha{\"e}l Beck and Marjan Moreels and Paul Jacquet and {Van Oostveldt}, Patrick and {De Vos}, Winnok and Sarah Baatout",
note = "Score = 10",
year = "2012",
month = "4",
day = "10",
doi = "10.3892/ijmm.2012.964",
language = "English",
volume = "30",
pages = "114--118",
journal = "International Journal of Molecular Medicine",
issn = "1107-3756",
publisher = "Spandidos Publications",
number = "1",

}

RIS - Download

TY - JOUR

T1 - X-irradiation induces cell death in fetal fibroblasts

AU - Beck, Michaël

AU - Moreels, Marjan

AU - Jacquet, Paul

AU - Van Oostveldt, Patrick

AU - De Vos, Winnok

AU - Baatout, Sarah

N1 - Score = 10

PY - 2012/4/10

Y1 - 2012/4/10

N2 - The impact of ionizing radiation on developing organisms has been widely studied for risk assessment purposes. Even though efforts have been made to decrease received doses to as low as reasonably achievable, the possibility of accidental exposure has to be considered as well. Mammalian gestation is usually divided into three periods. Radiation exposure during the ‘pre-implantation period’ may essentially result in embryonic mortality while exposure during the ‘organogenesis period’ may characteristically lead to malformations. In humans, the ‘fetal period’ is one of particular sensitivity to radiation induction of mental retardation, especially if the exposure occurs between weeks 8-15 of gestation. It is also admitted that prenatal irradiation may increase the risk of leukemia and childhood cancer, with an equal risk over the whole pregnancy. The aim of this study was to investigate the effects of moderate to high doses of X-irradiation on mouse skin fetal fibroblasts, one of the cell types subjected to the highest dose of radiation. Exposure of the cells to X-rays led to a rapid and significant increase in γ-H2AX foci, indicative of high levels of DNA double strand breaks.

AB - The impact of ionizing radiation on developing organisms has been widely studied for risk assessment purposes. Even though efforts have been made to decrease received doses to as low as reasonably achievable, the possibility of accidental exposure has to be considered as well. Mammalian gestation is usually divided into three periods. Radiation exposure during the ‘pre-implantation period’ may essentially result in embryonic mortality while exposure during the ‘organogenesis period’ may characteristically lead to malformations. In humans, the ‘fetal period’ is one of particular sensitivity to radiation induction of mental retardation, especially if the exposure occurs between weeks 8-15 of gestation. It is also admitted that prenatal irradiation may increase the risk of leukemia and childhood cancer, with an equal risk over the whole pregnancy. The aim of this study was to investigate the effects of moderate to high doses of X-irradiation on mouse skin fetal fibroblasts, one of the cell types subjected to the highest dose of radiation. Exposure of the cells to X-rays led to a rapid and significant increase in γ-H2AX foci, indicative of high levels of DNA double strand breaks.

KW - radiation

KW - fibroblasts

KW - fetal

KW - apoptosis

KW - DNA damage

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_121162

UR - http://knowledgecentre.sckcen.be/so2/bibref/9080

U2 - 10.3892/ijmm.2012.964

DO - 10.3892/ijmm.2012.964

M3 - Article

VL - 30

SP - 114

EP - 118

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

IS - 1

ER -

ID: 363126